Finerenone for Cardiorenal Protection in Diabetic CKD: Impact on Renal Function Decline and Heart Failure

NCT ID: NCT07326631

Last Updated: 2026-01-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2026-01-01

Study Completion Date

2026-07-01

Brief Summary

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To assess the effect of Finerinone on slowing renal function decline and improving cardiovascular outcomes, particularly heart failure risk, in patients with diabetic CKD.

Detailed Description

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Conditions

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Diabetic Kidney Disease (DKD) Heart Failure

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Finerenone Group

Finerenone Drug

Group Type EXPERIMENTAL

Finerenone

Intervention Type DRUG

To assess the effect of Finerinone on slowing renal function decline and improving cardiovascular outcomes, particularly heart failure risk, in patients with diabetic CKD.

Interventions

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Finerenone

To assess the effect of Finerinone on slowing renal function decline and improving cardiovascular outcomes, particularly heart failure risk, in patients with diabetic CKD.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Adults aged ≥18 years.
* Diagnosed cases of type 2 diabetes mellitus.
* Chronic kidney disease with eGFR 25-90 mL/min/1.73m² and/or UACR ≥30 mg/g.
* On stable ACE inhibitor or ARB therapy for at least 4 weeks.
* Serum potassium ≤4.8 mmol/L.
* Provided written informed consent.

Exclusion Criteria

* Symptomatic heart failure (NYHA class II-IV).
* eGFR \<25 mL/min/1.73m² or on maintenance dialysis.
* Known non-diabetic kidney disease.
* Recent major cardiovascular event (within 30 days).
* Serum potassium \>4.8 mmol/L or history of severe hyperkalaemia.
* Contraindication or hypersensitivity to finerenone.
* Pregnancy or lactation.
* Any condition limiting compliance or follow-up.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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College of Physicians and Surgeons Pakistan

OTHER

Sponsor Role lead

Responsible Party

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Muhammad Awais Danish

Dr

Responsibility Role PRINCIPAL_INVESTIGATOR

Central Contacts

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Muhammad Awais Danish, FCPS (Internal Medicine)

Role: CONTACT

923037589797

Provided Documents

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Document Type: Study Protocol, Statistical Analysis Plan, and Informed Consent Form

View Document

Related Links

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Other Identifiers

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22126

Identifier Type: -

Identifier Source: org_study_id

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