Bevacizumab (Avastin) in Unresectable/Recurrent Hemangioblastoma From Von-Hippel-Lindau Disease

NCT ID: NCT01015300

Last Updated: 2012-05-11

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: EARLY_PHASE1
• Total Enrollment: 1 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2009-12-31
• Study Completion Date: 2012-04-30

Brief Summary

Von Hippel-Lindau (VHL) disease is an inherited syndrome manifested by a variety of benign and malignant tumors. Hemangioblastomas are the most common lesion associated with VHL disease affecting 60-84% of patients with a mean age at diagnosis of 29 years. Standard treatment for this disease is by surgery or radiotherapy. No approved systemic therapy yet exists. Patients with VHL have an increased growth factor production, specifically vascular endothelial growth factor (VEGF), resulting in angiogenesis (growth of blood vessels). Studies show that Bevacizumab inhibits the growth of VEGF protein and will block the VEGF-driven angiogenesis and result in stabilization and regression of hemangioblastomas in VHL disease patients. The dose of bevacizumab will be 10 mg/kg every two weeks for up to 6 months.

Conditions

Hemangioblastomas; Von Hippel Lindau Disease

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Interventions

Avastin

Patients will receive Bevacizumab (Avastin) 10mg/kg IV every two weeks for 6 months

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• One or more CNS hemangioblastomas not amendable to surgical resection or recurrent post resection
• Confirmed diagnosis of von-Hippel-Lindau disease
• No prior treatment with VEGF inhibitors
• Index hemangioblastomas lesion at least 5mm on MRI
• No major bleeding event from hemangioblastoma within 90 days
• KPS > or equal to 60%
• Age > or equal to 18 years

Exclusion Criteria

• Prior treatment with VEGF inhibitors
• Major bleeding event from hemangioblastoma within 90 days
• Inability to comply with study and/or follow up procedures
• Life expectancy of less than 12 weeks
• Current or recent (within 4 weeks of the first infusion of this study) participation in an experimental drug study other than a Genentech sponsored bevacizumab cancer study
• Active malignancy will be permissible if treating physician deems that concurrent administration of bevacizumab is not contraindicated and that the patient would be able to complete with the other parameters of the protocol

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Genentech, Inc.

INDUSTRY

Sponsor Role: collaborator

Dartmouth-Hitchcock Medical Center

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

J Marc Pipas, MD

Role: PRINCIPAL_INVESTIGATOR

Dartmouth-Hitchcock Medical Center

Locations

Dartmouth Hitchcock Medical Center

Lebanon, New Hampshire, United States

Countries

United States

Other Identifiers

D0904

Identifier Type: -

Identifier Source: org_study_id