Study to Assess the Efficacy and Safety of GF-001001-00 Cream in Secondarily-Infected Traumatic Lesions

NCT ID: NCT01005771

Last Updated: 2010-06-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-09-30

Study Completion Date

2010-03-31

Brief Summary

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This is a double-blind, randomized, placebo-controlled, parallel-group, dose-finding study.

Detailed Description

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200 eligible patients will be included in the double-blind phase (50 in each group, randomised 1:1:1:1 to GF-001001-00 at a concentration of 0.25%, 1% or 2% or placebo).

Randomised patients will apply the study medication as follows depending on their assigned treatment group.

* GF-001001-00 2%, 2 times daily, for 7 days
* GF-001001-00 1%, 2 times daily, for 7 days
* GF-001001-00 0.25%, 2 times daily, for 7 days
* Placebo, 2 times daily, for 7 days

The first application will be done after randomisation at Visit 1 under the guidance of the investigator. Patients will return for control visits: Visit 2 (Day 5) and Visit 3 (Day 7), after randomisation. Patients will return for the Final Visit (Visit 4, Day 14 after initiation of treatment).

Primary objective:

To determine the most effective dose of GF-001001-00 cream for treatment of adult patients with secondarily infected traumatic lesions.

Primary efficacy endpoint:

Clinical response (success or failure) at the Final Visit (Day 14) in the ITTC population.

Conditions

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Secondarily Infected Traumatic Lesions

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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GF-001001-00 2%

Group Type EXPERIMENTAL

GF-001001-00

Intervention Type DRUG

GF-001001-00 2%, 1% and 0.25% twice daily for 7 days

GF-001001-00 1%

Group Type EXPERIMENTAL

GF-001001-00

Intervention Type DRUG

GF-001001-00 2%, 1% and 0.25% twice daily for 7 days

GF-001001-00 0.25%

Group Type EXPERIMENTAL

GF-001001-00

Intervention Type DRUG

GF-001001-00 2%, 1% and 0.25% twice daily for 7 days

Placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Matching placebo

Interventions

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GF-001001-00

GF-001001-00 2%, 1% and 0.25% twice daily for 7 days

Intervention Type DRUG

Placebo

Matching placebo

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Males and females ≥ 18 years of age.
* Presence of small laceration, sutured wound, abrasion or burn, which has a secondary bacterial infection.

Exclusion Criteria

* None.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ferrer Internacional S.A.

INDUSTRY

Sponsor Role lead

Responsible Party

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Ferrer Internacional S.A.

Locations

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Dermatologische Praxis

Mahlow, , Germany

Site Status

Countries

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Germany

Other Identifiers

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P-080623-01

Identifier Type: -

Identifier Source: org_study_id

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