Clinical Evaluation of the Efficacy of a Medical Device in Treatment of Toenail Onychomycosis

NCT ID: NCT03289871

Last Updated: 2017-09-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

112 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-01-31

Study Completion Date

2015-11-30

Brief Summary

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This study evaluates the effect of the medical device "Excilor® Fungal Nail Infection" in the treatment of toenail onychomycosis. Half of the participants will receive the tested product and the other half will receive a comparator (Amorolfin 5%). Patients will be followed during 6 months.

Detailed Description

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Conditions

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Onychomycosis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Excilor

2 applications per day for 6 months

Group Type EXPERIMENTAL

Excilor

Intervention Type DEVICE

Loceryl 5%

1 application per week for 6 months

Group Type ACTIVE_COMPARATOR

Loceryl 5%

Intervention Type DRUG

Interventions

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Excilor

Intervention Type DEVICE

Loceryl 5%

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Subject having given her/his informed, written consent,
* Subject cooperative and aware of the modalities of use and the necessity and duration of the controls so that perfect adhesion to the protocol can be expected.
* Subject being psychologically able to understand information and to give their/his/her consent.
* Age: more than 18 years.
* Subject with superficial onychomycosis on at least one great toenail or light to moderate disto-lateral onychomycosis (without matrix involvement and involvement \<2/3 of the tablet).
* Subject with positive results of KOH staining.
* Subject having stopped any systemic antifungal treatment since at least 6 months before inclusion and/or any topical antifungal treatment since at least 3 months before inclusion.
* Female subjects of childbearing potential should use an accepted contraceptive regimen since at least 12 weeks before the beginning of the study, during all the study and at least 1 month after the study end.

Exclusion Criteria

* Subject considered by the Investigator likely to be non-compliant with the protocol.
* Patient enrolled in another clinical trial during the test period.
* Woman being pregnant, nursing or planning a pregnancy during the course of this study.
* Subject having a known allergy to one of the constituents of the tested products.
* Patient suffering from serious or progressive diseases (to investigator's discretion), such as diabetes, peripheral circulatory disease, HIV, psoriasis, lichen planus, immunosuppressive pathology….
* Subject with cutaneous pathology on studied zone (other than onychomycosis like angioma, dermatitis…).
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Oystershell NV

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Nejib Doss, MD

Role: PRINCIPAL_INVESTIGATOR

Principal Instruction military hospital of Tunis

Locations

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Hospital Habib Thameur

Tunis, , Tunisia

Site Status

Principal instruction military hospital

Tunis, , Tunisia

Site Status

Countries

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Tunisia

Other Identifiers

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14E0752

Identifier Type: -

Identifier Source: org_study_id