DNA Microarray Analysis of Gene Expression in Chronic Rhinosinusitis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2005-03-31

Study Completion Date

2008-11-18

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Analysis of differential gene expression in patients with chronic rhinosinusitis without polyps compared to unaffected patients. Correlation of abnormal gene expression with surgical outcomes.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Microarray Analysis of Sinus Samples From Patients With and Without Chronic Rhinosinusitis.

NCT00847041

Chronic Rhinosinusitis

COMPLETED

Tapering of Biologics in Chronic Rhinosinusitis With Nasal Polyps

NCT07187583

Chronic Rhinosinusitis With Nasal Polyps

RECRUITING PHASE4

Clinical Study to Improve Diagnosis and Treatment of Sinusitis

NCT00962689

Chronic Sinusitis

COMPLETED

The Sinonasal Microbiome

NCT06822725

Sinonasal Disorder Chronic Rhinosinusitis (Diagnosis)

ACTIVE_NOT_RECRUITING

Dupilumab Treatment Effects in an Ethnically Diverse Population With Chronic Rhinosinusitis With Nasal Polyposis

NCT05246267

Chronic Rhinosinusitis With Nasal Polyps

RECRUITING

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Chronic Rhinosinusitis w/o Nasal Polyps

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

1

Chronic Rhinosinusitis w/o nasal polyps

No interventions assigned to this group

2

No sinus disease

No interventions assigned to this group

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

Affected patients:

* Two or more of the following symptoms should be present for 12 weeks or more: anterior mucopurulent drainage, posterior mucopurulent drainage; nasal obstruction; and facial pain-pressure-fullness.

* Signs of nasal inflammation such as discolored mucus, edema of the middle meatus or ethmoid area should be documented by endoscopy.
* The symptoms of rhinosinusitis have failed to resolve or have recurred after a treatment course with antibiotics and nasal and/or oral steroids.
* The diagnosis of rhinosinusitis should be confirmed with a CT scan.
* Patients deny recent (within one year) cigarette smoking or exposure to inhaled substances that are potentially harmful to respiratory epithelium
* Patients were not previously diagnosed with reactive airway disease or aspirin sensitivity.
* Patients also must meet the standard criteria for endoscopic sinus surgery and scheduled to undergo their procedure at MMC.

Unaffected Patients:

Patients undergoing elective nasal surgery at MMC.

* Patients deny symptoms of allergic rhinitis such as nasal congestion, nasal discharge, itching, sneezing.
* Patients deny symptoms of chronic or acute rhinosinusitis such as nasal obstruction, facial pain-fullness-pressure, anosmia, anterior and/or posterior mucopurulent drainage.
* Nasal endoscopy showed no evidence of nasal inflammatory disease, such as erythema, edema, polyps, or discolored mucus.
* Patients do not have history of prior sinus surgeries and were not previously diagnosed with CRS.

1. Patients deny recent (within one year) cigarette smoking or exposure to inhaled substances that are potentially harmful to respiratory epithelium.
2. Patients were not diagnosed with reactive airway disease or aspirin sensitivity.
* The absence of evidence of inflammation, such as inflammatory infiltrate or epithelial dysplasia on histopathologic exam of nasal mucosa obtained during surgical procedure.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No