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Investigate the Role of microRNA in Chronic Rhinosinusitis From DC-Th Axis

NCT ID: NCT02325596

Last Updated: 2014-12-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

70 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-07-31

Study Completion Date

2016-12-31

Brief Summary

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This study aimed to evaluate the upstream events of Th17/Treg imbalance in CRS and their immune regulatory factors. Then the investigators aimed to explore the regulatory role of miRNA on DC-Th axis and its dysfunction in the pathogenesis of CRS, in order to determine the miRNA expression profile in CRS and clarify the role of miRNA in the pathogenesis of CRS by regulating the DC-Th axis.

Detailed Description

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Chronic rhinosinusitis (CRS), commonly encountered in the field of clinical otorhinolaryngology, is still a challenging proposition for doctors because of its high incidence and the unsatisfactory treatment outcomes. Nowadays, studies on the pathogenesis of NP are still attached great importance by researchers from each country. NP has become a global health problem with a considerable socioeconomic burden. Recently, research showed that the impaired balance of Th17/Treg was the significant basis of NP. Nevertheless, the pathogenesis of Th17/Treg imbalance was unclear. In this study, DC-Th axis was designed as the main line, and the regulation of miRNA on DC was designed as the entry point. This study aimed to evaluate the upstream events of Th17/Treg imbalance in CRS and their immune regulatory factors. Then the investigators aimed to explore the regulatory role of miRNA on DC-Th axis and its dysfunction in the pathogenesis of CRS, in order to determine the miRNA expression profile in CRS and clarify the role of miRNA in the pathogenesis of CRS by regulating the DC-Th axis. This study will play an important role in clarifying the pathogenesis of CRS eventually and will fill the blanks of the research between miRNA and CRS in the investigators'country. This study is with important clinical value for establishing control strategies for CRS.

Conditions

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Rhinosinusitis

Keywords

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Chronic rhinosinusitis microRNA dendritic cell helper T cell

Study Design

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Observational Model Type

CASE_CONTROL

Study Groups

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control

Patients with only nasal septum deviation

miRNA mimics or inhibitors

Intervention Type GENETIC

DCs are transfected by the miRNA mimics or inhibitors after they are separated from peripheral blood mononuclear cells in CRS patients

CRS sNP

Chronic Rhinosinusitis patients without nasal polyps

miRNA mimics or inhibitors

Intervention Type GENETIC

DCs are transfected by the miRNA mimics or inhibitors after they are separated from peripheral blood mononuclear cells in CRS patients

atopic CRS wNP

Chronic Rhinosinusitis patients with allergic constitution and nasal polyps

miRNA mimics or inhibitors

Intervention Type GENETIC

DCs are transfected by the miRNA mimics or inhibitors after they are separated from peripheral blood mononuclear cells in CRS patients

non-atopic CRS wNP

Chronic Rhinosinusitis patients with nasal polyps but not allergic constitution

miRNA mimics or inhibitors

Intervention Type GENETIC

DCs are transfected by the miRNA mimics or inhibitors after they are separated from peripheral blood mononuclear cells in CRS patients

Interventions

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miRNA mimics or inhibitors

DCs are transfected by the miRNA mimics or inhibitors after they are separated from peripheral blood mononuclear cells in CRS patients

Intervention Type GENETIC

Eligibility Criteria

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Inclusion Criteria

1. CRS diagnosis is accord with diagnostic criteria of The European nasal sinusitis, nasal polyps guidelines (EPOS 2012) .
2. Selected subjects are stopped using systemic or topical corticosteroids in one month before experiment.
3. All the patients have sinus CT and nasal endoscopy and allergen Skin Prick Test in preoperative.
4. Aged from 18 to 75 years old.
5. Woman or man.

Exclusion Criteria

1. Choanal polyp, fungal nasal sinusitis, cystic fibrosis.
2. Acute upper respiratory tract infection and other diseases associated with the body.
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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First Affiliated Hospital of Chongqing Medical University

OTHER

Sponsor Role lead

Responsible Party

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Guo-hua Hu

Investigate the Role of microRNA in Chronic Rhinosinusitis From DC-Th Axis

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Guo-hua Hu HG Guo-hua Hu, MD

Role: PRINCIPAL_INVESTIGATOR

First Affiliated Hospital of Chongqing Medical University

Locations

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The First Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, China

Site Status

Countries

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China

References

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Ma ZX, Tan X, Shen Y, Ke X, Yang YC, He XB, Wang ZH, Dai YB, Hong SL, Hu GH. MicroRNA expression profile of mature dendritic cell in chronic rhinosinusitis. Inflamm Res. 2015 Nov;64(11):885-93. doi: 10.1007/s00011-015-0870-5. Epub 2015 Sep 4.

Reference Type DERIVED
PMID: 26337346 (View on PubMed)

Other Identifiers

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NSFC-81271061

Identifier Type: -

Identifier Source: org_study_id