Glucose-dependent Insulinotropic Polypeptide (GIP) and Lipid Metabolism

NCT ID: NCT00999271

Last Updated: 2009-10-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-08-31

Study Completion Date

2009-09-30

Brief Summary

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The aim of this proposal is to examine whether endogenous GIP and exogenous GIP alone and in combination with insulin affect gastric emptying (GE), appetite, energy intake, energy expenditure (EE) and plasma levels of triglycerides (TAG), free fatty acids FFA) and glycerol in man.

Detailed Description

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Conditions

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Healthy Subjects

Study Design

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Observational Model Type

CASE_CONTROL

Study Groups

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Healthy subjects

30 healthy subjects without family history of diabetes or gastrointestinal disease, a normal oral glucose tolerance test (OGTT) and no intake of medicine

Incretin hormone - Glucose-dependent insulinotropic polypeptide (GIP)

Intervention Type OTHER

two different dosages:

* 0.8 pmol/kg/min
* 1.5 pmol/kg/min for 300 minutes

Interventions

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Incretin hormone - Glucose-dependent insulinotropic polypeptide (GIP)

two different dosages:

* 0.8 pmol/kg/min
* 1.5 pmol/kg/min for 300 minutes

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Informed oral and written consent
* Caucasians over the age of 18 years
* Normal 75 g oral glucose tolerance test (OGTT)
* Normal blood haemoglobin concentration
* Normal plasma lipid profile

Exclusion Criteria

* First-degree relatives with diabetes and familial hypertriglyceridemia
Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Hvidovre University Hospital

OTHER

Sponsor Role lead

Responsible Party

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University of Copenhagen

Locations

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Hvidovre Hospital

Hvidovre, , Denmark

Site Status

Countries

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Denmark

Other Identifiers

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HD-2009-0025

Identifier Type: -

Identifier Source: org_study_id

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