Study of Postprandial Incretin Response in Women With Gestational Diabetes

NCT ID: NCT01274052

Last Updated: 2011-01-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

19 participants

Study Classification

OBSERVATIONAL

Study Start Date

2007-03-31

Study Completion Date

2008-07-31

Brief Summary

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The researchers investigated nineteen pregnant women in third trimester and again postpartum. At the experimental days we performed a mealtest and drew blood for analyses of glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), insulin, C-peptide and glucagon.

The researchers aimed to investigate whether women with gestational diabetes mellitus exhibit decreased postprandial GLP-1 responses, and if so, whether this deficiency ceases following delivery when normal glucose tolerance is reestablished.

Detailed Description

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The researchers investigated nineteen pregnant women in third trimester and again postpartum. At the experimental days we performed a mealtest and drew blood for analyses of glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), insulin, C-peptide and glucagon.

The researchers aimed to investigate whether women with gestational diabetes mellitus exhibit decreased postprandial GLP-1 responses, and if so, whether this deficiency ceases following delivery when normal glucose tolerance is reestablished.

Conditions

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Gestational Diabetes Mellitus

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Gestational Diabetes Mellitus

Women with Gestational Diabetes Mellitus

Meal test

Intervention Type OTHER

Liquid meal test

Normal Glucose Tolerance

Women with Normal Glucose Tolerance

Meal test

Intervention Type OTHER

Liquid meal test

Interventions

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Meal test

Liquid meal test

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Normal haemoblobin
* Willingness to participate

Exclusion Criteria

* First degree relative with diabetes
* Diabetes before pregnancy
* Positive islet cell- and GAD-65 autoantibodies
Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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The Danish Diabetes Association

OTHER

Sponsor Role collaborator

Aase and Ejnar Danielsens Foundation

OTHER

Sponsor Role collaborator

The Novo Nordic Foundation

OTHER

Sponsor Role collaborator

University Hospital, Gentofte, Copenhagen

OTHER

Sponsor Role lead

Responsible Party

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Department of Internal Medicine F, University Hospital, Gentofte, Copenhagen

Principal Investigators

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Filip K Knop, MD PhD

Role: PRINCIPAL_INVESTIGATOR

Diabetes Research Division, Gentofte Hopsital

Locations

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Department of Internal Medicine, Glostrup Hospital

Glostrup Municipality, , Denmark

Site Status

Countries

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Denmark

References

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Hare KJ, Bonde L, Svare JA, Randeva HS, Asmar M, Larsen S, Vilsboll T, Knop FK. Decreased plasma chemerin levels in women with gestational diabetes mellitus. Diabet Med. 2014 Aug;31(8):936-40. doi: 10.1111/dme.12436. Epub 2014 Apr 1.

Reference Type DERIVED
PMID: 24628007 (View on PubMed)

Other Identifiers

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KA-060015

Identifier Type: -

Identifier Source: org_study_id

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