A Long-Term Safety And Tolerability Extension Study Of Bapineuzumab In Alzheimer Disease Patients

NCT ID: NCT00998764

Last Updated: 2016-01-01

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE3

Total Enrollment

494 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-12-31

Study Completion Date

2012-11-30

Brief Summary

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The purpose of this study is to assess the long-term safety and tolerability of bapineuzumab in subjects with Alzheimer Disease who participated in study 3133K1-3001(NCT00676143). Over 250 sites will participate in over 26 countries. Subjects will receive bapineuzumab. Each subject's participation will last approximately 4 years.

Detailed Description

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Conditions

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Alzheimer Disease

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Bapineuzumab 0.5 mg/kg

Group Type EXPERIMENTAL

Bapineuzumab 0.5 mg/kg

Intervention Type DRUG

I.V., 0.5 mg/kg, infusion every 13 weeks for a total of 16 infusions.

Interventions

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Bapineuzumab 0.5 mg/kg

I.V., 0.5 mg/kg, infusion every 13 weeks for a total of 16 infusions.

Intervention Type DRUG

Other Intervention Names

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AAB-001

Eligibility Criteria

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Inclusion Criteria

* Subject has completed study 3133K1-3001 (Week 78) and brain magnetic resonance imaging (MRI) scan consistent with the diagnosis of Alzheimer Disease
* Mini-Mental Status Examination (MMSE) \>=10 at screening
* Caregiver able to attend all clinic visits with subject

Exclusion Criteria

* Any medical or psychiatric contraindication or clinically significant abnormality that, in the investigator's judgment, will substantially increase the risk associated with the subject's participation in and completion of the study or could preclude the evaluation of the subject's response.
* Any significant brain MRI abnormality.
* Use of any investigational drugs or devices, other than bapineuzumab within the last 60 days prior to screening
Minimum Eligible Age

51 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Pfizer

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pfizer CT.gov Call Center

Role: STUDY_DIRECTOR

Pfizer

Locations

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University Of Alabama at Birmingham

Birmingham, Alabama, United States

Site Status

UAB Center for Psychiatric Medicine

Birmingham, Alabama, United States

Site Status

University of Alabama at Birmingham

Birmingham, Alabama, United States

Site Status

University of Alabama-Birmingham

Birmingham, Alabama, United States

Site Status

Dedicated Clinical Research

Goodyear, Arizona, United States

Site Status

Banner Alzheimer's Institute

Phoenix, Arizona, United States

Site Status

Banner Good Samaritan Medical Center (Imaging

Phoenix, Arizona, United States

Site Status

Jeffrey S. Gitt

Phoenix, Arizona, United States

Site Status

Hope Research Institute

Phoenix, Arizona, United States

Site Status

Clinical Trials, Inc.

Little Rock, Arkansas, United States

Site Status

San Francisco Clinical Research Center

San Francisco, California, United States

Site Status

Alpine Clinical Research Center, Inc.

Boulder, Colorado, United States

Site Status

Associated Neurologist, PC

Boulder, Colorado, United States

Site Status

Mile High Research Center

Denver, Colorado, United States

Site Status

Associated Neurologists of Southern Connecticut, P.C.

Fairfield, Connecticut, United States

Site Status

Bendheim Infusion Center, Greenwich Hospital

Greenwich, Connecticut, United States

Site Status

Center for Healthy Aging, Greenwich Hospital

Greenwich, Connecticut, United States

Site Status

Research Center for Clinical Studies, Inc.

Norwalk, Connecticut, United States

Site Status

JEM Research LLC

Atlantis, Florida, United States

Site Status

Medical Specialists of the Palm Beaches

Atlantis, Florida, United States

Site Status

Brain Matters Research

Delray Beach, Florida, United States

Site Status

Compass Research, LLC

Orlando, Florida, United States

Site Status

Palm Beach Neurological Center, Advanced Research Consultants, Inc.

Palm Beach Gardens, Florida, United States

Site Status

Neurostudies, Inc

Port Charlotte, Florida, United States

Site Status

Southwest Florida Infusion Care, Inc.

Port Charlotte, Florida, United States

Site Status

Roskamp Institute

Sarasota, Florida, United States

Site Status

USF Health Byrd Alzheimer's Institute

Tampa, Florida, United States

Site Status

Neuroscience Research Institute, LLC

Lawrenceville, Georgia, United States

Site Status

Neurostudies.net

Lawrenceville, Georgia, United States

Site Status

Alexian Brothers Neurosciences Institute Clinical Research

Elk Grove Village, Illinois, United States

Site Status

Southern Illinois University School of Medicine Department

Springfield, Illinois, United States

Site Status

Lake Charles Clinical Trials

Lake Charles, Louisiana, United States

Site Status

Neuroscience Research of the Berkshires

Pittsfield, Massachusetts, United States

Site Status

Springfield Neurology Associates, LLC

Springfield, Massachusetts, United States

Site Status

Michigan State University

East Lansing, Michigan, United States

Site Status

Michigan State University

East Lansing, Michigan, United States

Site Status

Neurological Research Center of Hattiesburg Clinic

Hattiesburg, Mississippi, United States

Site Status

The Center for Pharmaceutical Research, P.C.

Kansas City, Missouri, United States

Site Status

Memory Enhancement Center of America, Inc.

Eatontown, New Jersey, United States

Site Status

Alzheimer's Research Corp./Merician Institute for Aging

Paterson, New Jersey, United States

Site Status

Toms River X-Ray, CT & MRI

Toms River, New Jersey, United States

Site Status

MDR

Liverpool, New York, United States

Site Status

Neurological Care of Central New York

Liverpool, New York, United States

Site Status

Carolina Neuropsychological Services, Inc.

Raleigh, North Carolina, United States

Site Status

Healthsouth Blue Ridge Surgery Center

Raleigh, North Carolina, United States

Site Status

Raleigh Neurology Associates

Raleigh, North Carolina, United States

Site Status

Wake Radiology Associates

Raleigh, North Carolina, United States

Site Status

Ohio State Unviersity

Columbus, Ohio, United States

Site Status

Summit Research Network(Oregon) Inc.

Portland, Oregon, United States

Site Status

Providence Brain Institute-Cognitive Assessment Clinic

Portland, Oregon, United States

Site Status

Providence Brain Institute

Portland, Oregon, United States

Site Status

Abington Neurological Associates

Abington, Pennsylvania, United States

Site Status

Abington Neurological Assoc

Abington, Pennsylvania, United States

Site Status

Bington Memorial Hospital

Abington, Pennsylvania, United States

Site Status

Clinical Trial Center, LLC

Jenkintown, Pennsylvania, United States

Site Status

Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, United States

Site Status

Thomas Jefferson University

Philadelphia, Pennsylvania, United States

Site Status

Rhode Island Mood and Memory Research Institute

East Providence, Rhode Island, United States

Site Status

Medical University of South Carolina Hospitals and Clinics

Charleston, South Carolina, United States

Site Status

Medical University of South Carolina

Charleston, South Carolina, United States

Site Status

Medical University of South Carolina

North Charleston, South Carolina, United States

Site Status

Texas Neurology, P.A.

Dallas, Texas, United States

Site Status

Innovative Clinical Trials

San Antonio, Texas, United States

Site Status

Integra Clinical Research, LLC

San Antonio, Texas, United States

Site Status

Vista Infusions

San Antonio, Texas, United States

Site Status

Inventive Infusion Solutions

San Antonio, Texas, United States

Site Status

Hospital Italiano de Buenos Aires

Buenos Aires, , Argentina

Site Status

Gosford Hospital; Pharmacy Dept

Gosford, New South Wales, Australia

Site Status

Hornsby Hospital

Hornsby, New South Wales, Australia

Site Status

Royal Adelaide Memory Trials Centre

Adelaide, South Australia, Australia

Site Status

Memory Unit 5C, Department of Neurology

Woodville South, South Australia, Australia

Site Status

The Queen Elizabeth Hospital

Woodville South, South Australia, Australia

Site Status

Heidelberg Repatriation Hospital

Heidelberg West, Victoria, Australia

Site Status

Hollywood Hospital; Pharmacy Dept

Nedlands, Western Australia, Australia

Site Status

The McCusker Foundation for Alzheimer's Disease Research

Nedlands, Western Australia, Australia

Site Status

ZNA Middelheim

Antwerp, , Belgium

Site Status

AZ Sint-Jan Brugge-Oostende AV

Bruges, , Belgium

Site Status

Cliniques Universitaires St Luc

Brussels, , Belgium

Site Status

Universitair Ziekenhuis Gasthuisberg

Leuven, , Belgium

Site Status

H.-Hartziekenhuis Roeselare-Menen

Roeselare, , Belgium

Site Status

Psicomedica Research Group

Santiago, Chile, Chile

Site Status

Ita-Suomen Yliopisto

Kuopio, , Finland

Site Status

University of Turku/CRST

Turku, , Finland

Site Status

CHU de Dijon

Dijon, France, France

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Hôpital Roger Salengro

Lille, France, France

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Hôpital Pitié-Salpétrière

Paris, France, France

Site Status

CHU Hôpital Pellegrin-Tripode

Bordeaux, , France

Site Status

Hopital Neurologique

Bron, , France

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CHU de Caen

Caen, , France

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Hôpitaux Civils de Colmar

Colmar, , France

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Hôpital la Timone

Marseille, , France

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Hôpital la Timone

Marseille, , France

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CHU Hôpital Gui de Chaulliac

Montpellier, , France

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CHU Nord - Hôpital Guillaume et René Laënnec

Nantes - Saint Herblain, , France

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Hôpital Cimiez

Nice, , France

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CHU La Milétrie

Poitiers, , France

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C.H.U de Reims

Reims, , France

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Department de Radiologie et d'Imagerie Medicale, Hopital Pontchaillou

Rennes, , France

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CHRU Hôtel Dieu

Rennes, , France

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Centre Hospitalier Universitaire Charles Nicolle

Rouen, , France

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Hôpital Purpan

Toulouse, , France

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CHU Purpan - Hôpital Casselardit

Toulouse, , France

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Sezione di Neurologia - Dipartimento di Neuroscienze

Ancona, , Italy

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Dipartimento di Neuroscienze,

Catania, , Italy

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Fondazione IRCCS- Istituto Neurologico Carlo Besta

Milan, , Italy

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Unita' Operativa C - Riabilitazione Neurologica

Roma, , Italy

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Nagoya City University Hospital

Nagoya, Aichi-ken, Japan

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Yachiyo Hospital

Aichi, , Japan

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Kashiwado Hospital

Chiba, , Japan

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National Hospital Organization Chiba-East Hospital

Chiba, , Japan

Site Status

Nippon Medical School Chiba Hokusoh Hospital

Chiba, , Japan

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National Hospital Organization Kokura Medical Center

Fukuoka, , Japan

Site Status

Maebashi Red Cross Hospital

Gunma, , Japan

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Gunma University Hospital

Gunma, , Japan

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Shinozuka Hospital

Gunma, , Japan

Site Status

National Hospital Organization Hiroshima-nishi Medical Ctr.

Hiroshima, , Japan

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Kobe University Hospital

Hyōgo, , Japan

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Kagawa University Hospital

Kagawa, , Japan

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Nippon Medical School Musashi Kosugi Hospital

Kanagawa, , Japan

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Rakuwakai Otowa Hospital

Kyoto, , Japan

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National Hospital Organization Minami-Kyoto Hospital

Kyoto, , Japan

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National Hospital Organization Maizuru Medical Center

Kyoto, , Japan

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National Hospital Organization Matsumoto Medical Center

Nagano, , Japan

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National Hospital Organization Niigata National Hospital

Niigata, , Japan

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Okayama University Hospital

Okayama, , Japan

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National Hospital Organization Minami-Okayama Medical Center

Okayama, , Japan

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Osaka City University Hospital

Osaka, , Japan

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Kansai Medical University Takii Hospital

Osaka, , Japan

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Juntendo University Hospital

Tokyo, , Japan

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Juntendo Tokyo Koto Geriatric Medical Center

Tokyo, , Japan

Site Status

Tokyo Metropolitan Health and Med. Treatment Co. Ebara Hosp

Tokyo, , Japan

Site Status

Tokyo Medical University Hospital

Tokyo, , Japan

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Tokyo Medical University Hachioji Medical Center

Tokyo, , Japan

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National Hospital Organization Tokyo National Hospital

Tokyo, , Japan

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Geriatry

's-Hertogenbosch, , Netherlands

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Jeroen Bosch Ziekenhuis

's-Hertogenbosch, , Netherlands

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Vrije Universiteit Medisch Centrum

Amsterdam, , Netherlands

Site Status

Medisch Centrum Leeuwarden

Leeuwarden, , Netherlands

Site Status

The Memory Clinic Limited

Auckland, , New Zealand

Site Status

Christchurch Hospital

Christchurch, , New Zealand

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Signet Research

Christchurch, , New Zealand

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NZOZ Neuro-kard

Poznan, Poland, Poland

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Pallmed Spolka z o.o.

Bydgoszcz, , Poland

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MCD Voxel

Poznan, , Poland

Site Status

Pracownia Rezonansu Magnetycznego

Warsaw, , Poland

Site Status

SP ZOZ Szpital Wolski

Warsaw, , Poland

Site Status

Samodzielny Publiczny Centralny Szpital Kliniczny

Warsaw, , Poland

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Hospitais Da Universidade De Coimbra

Coimbra, Coimbra District, Portugal

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Hospital Fernando da Fonseca

Amadora, Lisbon District, Portugal

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Hospital Santa Maria

Lisbon, Lisbon District, Portugal

Site Status

Univerzitna nemocnica Bratislava

Bratislava, , Slovakia

Site Status

Vseobecna nemocnica Rimavska Sobota

Rimavská Sobota, , Slovakia

Site Status

Boithuso Caregivers

Johannesburg, Gauteng, South Africa

Site Status

The Osteoporosis and Memory Centre

Johannesburg, Gauteng, South Africa

Site Status

St Augustine's Medical Centre 2

Durban, KwaZulu-Natal, South Africa

Site Status

Hospital General Universitario de Elche

Elche, Alicante, Spain

Site Status

Hospital Universitario Son Espases

Palma de Mallorca, Balearic Islands, Spain

Site Status

CLONUS

Palma de Mallorca, Balearic Islands, Spain

Site Status

Hospital del Mar

Barcelona, Barcelona, Spain

Site Status

Fundacio ACE Institut Catala de Neurociences Aplicades

Barcelona, Barcelona, Spain

Site Status

Clinica CIMA

Barcelona, Barcelona, Spain

Site Status

Hospital Mutua de Terrasa

Terrassa, Barcelona, Spain

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Hospital Divino Valles

Burgos, Burgos, Spain

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Hospital Virgen del Puerto

Plasencia, Caceres, Spain

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Hospital de la Princesa

Madrid, Madrid, Spain

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Hospital Clinico San Carlos

Madrid, Madrid, Spain

Site Status

Hospital Universitario La Paz

Madrid, Madrid, Spain

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Hospital de la Princesa

Madrid, , Spain

Site Status

Hospital Universitario Virgen de la Arrixaca

Murcia, , Spain

Site Status

Malmo University Hospital

Malmo, , Sweden

Site Status

Minnes- och geriatrikmottagningen

Uppsala, , Sweden

Site Status

Memory Clinic Neuro-Psychologie Zentrum

Basel, Canton of Basel-City, Switzerland

Site Status

Memory Service North, Grenoside Grange Hospital

Grenoside, Sheffield, United Kingdom

Site Status

Llandough Hospital, Universtity Hospital of Wales

Cardiff, Wales, United Kingdom

Site Status

MAC UK Neuroscience Ltd.

Bradford, , United Kingdom

Site Status

Clinical Investigation and Research Unit (CIRU)

Brighton, , United Kingdom

Site Status

Glasgow Memory Clinic

Glasgow, , United Kingdom

Site Status

Dept. of Neurosciences Charing Cross Hospital

London, , United Kingdom

Site Status

The Doctors Laboratory Ltd.

London, , United Kingdom

Site Status

Newcastle General Hospital

Newcastle upon Tyne, , United Kingdom

Site Status

Northampton General Hospital

Northampton, , United Kingdom

Site Status

Royal Hallamshire Hospital

Sheffield, , United Kingdom

Site Status

Victoria Hospital

Swindon, , United Kingdom

Site Status

Alliance Medical

Wakefield, , United Kingdom

Site Status

Countries

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United States Argentina Australia Belgium Chile Finland France Italy Japan Netherlands New Zealand Poland Portugal Slovakia South Africa Spain Sweden Switzerland United Kingdom

References

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Ivanoiu A, Pariente J, Booth K, Lobello K, Luscan G, Hua L, Lucas P, Styren S, Yang L, Li D, Black RS, Brashear HR, McRae T. Long-term safety and tolerability of bapineuzumab in patients with Alzheimer's disease in two phase 3 extension studies. Alzheimers Res Ther. 2016 Jun 23;8(1):24. doi: 10.1186/s13195-016-0193-y.

Reference Type DERIVED
PMID: 27334799 (View on PubMed)

Related Links

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Other Identifiers

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B2521004

Identifier Type: OTHER

Identifier Source: secondary_id

2009-015080-13

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

3133K1-3003

Identifier Type: -

Identifier Source: org_study_id

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