A Long-Term Safety and Tolerability Study in Subjects With Mild to Moderate Alzheimer's Disease

NCT ID: NCT00937352

Last Updated: 2013-12-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE3

Total Enrollment

896 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-07-31

Study Completion Date

2012-09-30

Brief Summary

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The purpose of this study is to assess the long-term safety and tolerability of Bapineuzumab (AAB-001, ELN115727) in subjects with Alzheimer's disease who participated in study ELN115727-301 or study ELN115727-302.

Detailed Description

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Conditions

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Alzheimer's Disease

Keywords

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Mild to moderate Alzheimer's disease

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Bapineuzumab 0.5 mg/kg

0.5 mg/kg

Group Type ACTIVE_COMPARATOR

Bapineuzumab

Intervention Type DRUG

0.5 mg/kg, administered via IV (in the vein) infusion every 13 weeks for 4 years.

1.0 mg/kg, administered via IV (in the vein) infusion every 13 weeks for 4 years.

Bapineuzumab 1.0 mg/kg

1.0 mg/kg

Group Type ACTIVE_COMPARATOR

Bapineuzumab

Intervention Type DRUG

0.5 mg/kg, administered via IV (in the vein) infusion every 13 weeks for 4 years.

1.0 mg/kg, administered via IV (in the vein) infusion every 13 weeks for 4 years.

Interventions

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Bapineuzumab

0.5 mg/kg, administered via IV (in the vein) infusion every 13 weeks for 4 years.

1.0 mg/kg, administered via IV (in the vein) infusion every 13 weeks for 4 years.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of probable AD
* Must have completed study 301 or study 302; and have completed Visit 15 (Week 78)
* Brain MRI scan to evaluate safety from Study 301 or 302 at Visit 14/Week 71
* Caregiver able to attend all clinic visits with patient

Exclusion Criteria

* Any new medical contraindication or clinically significant abnormality on physical, neurological, laboratory, vital signs or ECG examination (eg, atrial fibrillation) that precludes continued or initiation of treatment with bapineuzumab or participation in the study
* Screening visit brain MRI scan (MRI from Study 301 or 302 Visit 14/Week 71) indicative of any significant abnormality not approved by the medical monitor prior to enrollment
* Current use of experimental medications for AD (other than bapineuzumab) and all other experimental medications, herbal preparations containing Ginko biloba, and anticoagulants (except the use of aspirin 325mg/day or less, Plavix, and Persantine but not for stroke)
Minimum Eligible Age

51 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Pfizer

INDUSTRY

Sponsor Role collaborator

JANSSEN Alzheimer Immunotherapy Research & Development, LLC

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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University of Alabama Hospital

Birmingham, Alabama, United States

Site Status

Dedicated Clinical Research, Inc.

Goodyear, Arizona, United States

Site Status

Banner Alzheimer's Institute

Phoenix, Arizona, United States

Site Status

HOPE Research Institute, LLC

Phoenix, Arizona, United States

Site Status

Banner Research Institute

Sun City, Arizona, United States

Site Status

University of Arizona College of Medicine, Health Sciences Center

Tucson, Arizona, United States

Site Status

Northwest NeuroSpecialists, PLLC

Tucson, Arizona, United States

Site Status

Clinical Trials, Inc.

Little Rock, Arkansas, United States

Site Status

East Bay Physicians Medical Group

Berkeley, California, United States

Site Status

AVI Clinical Research

Carson, California, United States

Site Status

ATP Clinical Research, Inc.

Costa Mesa, California, United States

Site Status

Pharmacology Research Institute

Encino, California, United States

Site Status

Margolin Brain Institute

Fresno, California, United States

Site Status

Neurology Center of North Orange County

Fullerton, California, United States

Site Status

Coordinated Clinical Research

La Jolla, California, United States

Site Status

University of California San Diego

La Jolla, California, United States

Site Status

Senior Clinical Trials, Inc.

Laguna Hills, California, United States

Site Status

Collaborative NeuroScience Network, Inc.

Long Beach, California, United States

Site Status

Pharmacology Research Institute

Los Alamitos, California, United States

Site Status

UCLA Department of Neurology

Los Angeles, California, United States

Site Status

Pharmacology Research Institute

Newport Beach, California, United States

Site Status

Neurology Center

Oceanside, California, United States

Site Status

University of California, Irvine Medical Center

Orange, California, United States

Site Status

Neuro-Therapeutics, Inc.

Pasadena, California, United States

Site Status

Sutter Neuroscience Medical Group

Sacramento, California, United States

Site Status

University of California at Davis, Alzheimer's Disease Research Center

Sacramento, California, United States

Site Status

Artemis Institute for Clinical Research

San Diego, California, United States

Site Status

Sharp Mesa Vista Hospital

San Diego, California, United States

Site Status

San Francisco Clinical Research Center

San Francisco, California, United States

Site Status

University of California San Francisco

San Francisco, California, United States

Site Status

Neurological Research Institute

Santa Monica, California, United States

Site Status

Schuster Medical Research Institute

Sherman Oaks, California, United States

Site Status

Diablo Clinical Research, Inc

Walnut Creek, California, United States

Site Status

Alpine Clinical Research Center

Boulder, Colorado, United States

Site Status

Mile High Research Center

Denver, Colorado, United States

Site Status

Advanced Neurosciences Research, LLC

Fort Collins, Colorado, United States

Site Status

Associated Neurologists, PC

Danbury, Connecticut, United States

Site Status

Associated Neurologists of Southern Connecticut, P.C.

Fairfield, Connecticut, United States

Site Status

Institute for Neurodegenerative Disorders

New Haven, Connecticut, United States

Site Status

Yale University School of Medicine

New Haven, Connecticut, United States

Site Status

Research Center for Clinical Studies, Inc.

Norwalk, Connecticut, United States

Site Status

Chase Medical Research, LLC

Waterbury, Connecticut, United States

Site Status

Christiana Care Neurology Specialists

Newark, Delaware, United States

Site Status

Georgetown University Medical Center

Washington D.C., District of Columbia, United States

Site Status

JEM Research, LLC

Atlantis, Florida, United States

Site Status

Bradenton Research Center, Inc.

Bradenton, Florida, United States

Site Status

Quantum Laboratories, Inc.

Deerfield Beach, Florida, United States

Site Status

Brain Matters Research

Delray Beach, Florida, United States

Site Status

Neurologic Consultants, PA

Fort Lauderdale, Florida, United States

Site Status

Neuropsychiatric Research Center of Southwest Florida

Fort Myers, Florida, United States

Site Status

Clinical Physiology Associates, Inc

Fort Myers, Florida, United States

Site Status

Emerald Coast Mood and Memory, PA.

Fort Walton Beach, Florida, United States

Site Status

MD Clinical

Hallandale, Florida, United States

Site Status

Mayo Clinic College of Medicine

Jacksonville, Florida, United States

Site Status

Neurology Associates

Maitland, Florida, United States

Site Status

Melbourne Internal Medicine Associates

Melbourne, Florida, United States

Site Status

Pharmax Research Clinic, LLC

Miami, Florida, United States

Site Status

Miami Jewish Health Systems

Miami, Florida, United States

Site Status

Allied Clinical Trials Inc.

Miami, Florida, United States

Site Status

Miami Research Associates

Miami, Florida, United States

Site Status

Renstar Medical Research

Ocala, Florida, United States

Site Status

Compass Research, LLC

Orlando, Florida, United States

Site Status

Palm Beach Neurological Center, Advanced Research Consultants, Inc.

Palm Beach Gardens, Florida, United States

Site Status

Neurostudies, Inc.

Port Charlotte, Florida, United States

Site Status

The Roskamp Institute, Inc

Sarasota, Florida, United States

Site Status

Suncoast Neuroscience Associates, Inc.

St. Petersburg, Florida, United States

Site Status

Axiom Clinical Research of Florida

Tampa, Florida, United States

Site Status

Johnnie B. Byrd Sr. Alzheimer's Center and Research Institute

Tampa, Florida, United States

Site Status

Stedman Clinical Trials, LLC

Tampa, Florida, United States

Site Status

University of South Florida Suncoast Alzheimer's and Gerontology Center

Tampa, Florida, United States

Site Status

Premiere Research Institute

West Palm Beach, Florida, United States

Site Status

Emory University, School of Medicine

Atlanta, Georgia, United States

Site Status

Multiple Sclerosis Center of Atlanta

Atlanta, Georgia, United States

Site Status

NeuroTrials Research, Inc.

Atlanta, Georgia, United States

Site Status

Medical Research and Health Education Foundation, Inc.

Columbus, Georgia, United States

Site Status

Medical Research and Health Education Foundation, Inc

Columbus, Georgia, United States

Site Status

DeKalb Neurology Associates, LLC

Decatur, Georgia, United States

Site Status

Gwinnett Medical Center

Lawrenceville, Georgia, United States

Site Status

University of Chicago Medical Center

Chicago, Illinois, United States

Site Status

Alexian Brothers Neuroscience Institute

Elk Grove Village, Illinois, United States

Site Status

Methodist Medical Center of Illinois

Peoria, Illinois, United States

Site Status

Southern Illinois University School of Medicine

Springfield, Illinois, United States

Site Status

Elkhart Clinic, LLC

Elkhart, Indiana, United States

Site Status

Indiana University School of Medicine

Indianapolis, Indiana, United States

Site Status

The University of Kansas Medical Center

Kansas City, Kansas, United States

Site Status

MidAmerica Neuroscience Institute

Lenexa, Kansas, United States

Site Status

Associates in Neurology, PSC

Lexington, Kentucky, United States

Site Status

University of Kentucky

Lexington, Kentucky, United States

Site Status

Four Rivers Clinical Research, Inc.

Paducah, Kentucky, United States

Site Status

Lake Charles Clinical Trials

Lake Charles, Louisiana, United States

Site Status

J. Gary Booker, MD, APMC

Shreveport, Louisiana, United States

Site Status

Maine Medical Partners Neurology

Scarborough, Maine, United States

Site Status

CBH Health, LLC

Rockville, Maryland, United States

Site Status

Brigham and Women's Hospital, Dept. of Neurology

Boston, Massachusetts, United States

Site Status

Boston University School of Medicine

Boston, Massachusetts, United States

Site Status

ActivMed Practices and Research, Inc.

Haverhill, Massachusetts, United States

Site Status

Neurocare, Inc.

Newton, Massachusetts, United States

Site Status

Neuroscience Research of the Berkshires

Pittsfield, Massachusetts, United States

Site Status

Donald S. Marks, MD, PC

Plymouth, Massachusetts, United States

Site Status

Springfield Neurology Associates, LLC

Springfield, Massachusetts, United States

Site Status

University of Michigan Medical Center

Ann Arbor, Michigan, United States

Site Status

Henry Ford Hospital

Detroit, Michigan, United States

Site Status

Michigan State University

East Lansing, Michigan, United States

Site Status

Borgess Medical Center/Borgess Research Institute

Kalamazoo, Michigan, United States

Site Status

Mayo Clinic

Rochester, Minnesota, United States

Site Status

Hattiesburg Clinic

Hattiesburg, Mississippi, United States

Site Status

Center for Pharmaceutical Research

Kansas City, Missouri, United States

Site Status

Washington University School of Medicine

Saint Lous, Missouri, United States

Site Status

Saint Louis University School of Medicine

St Louis, Missouri, United States

Site Status

Deaconess Billings Clinical Research Center

Billings, Montana, United States

Site Status

Advanced Neurology Specialists

Great Falls, Montana, United States

Site Status

University of Nebraska Medical Center

Omaha, Nebraska, United States

Site Status

Memory Enhancement Center of America, Inc.

Eatontown, New Jersey, United States

Site Status

Alzheimer's Research Corporation

Paterson, New Jersey, United States

Site Status

Global Medical Institutes, LLC

Princeton, New Jersey, United States

Site Status

Shore Neurology, PA

Toms River, New Jersey, United States

Site Status

Albuquerque Neuroscience, Inc.

Albuquerque, New Mexico, United States

Site Status

Upstate Clinical Research, LLC

Albany, New York, United States

Site Status

Neurological Associates of Albany, PC

Albany, New York, United States

Site Status

Neuroscience Research Center at Albany Medical Center

Albany, New York, United States

Site Status

Advanced BioBehavioral Sciences

Elmsford, New York, United States

Site Status

Empire Neurology, PC

Latham, New York, United States

Site Status

Neurological Care of Central New York

Liverpool, New York, United States

Site Status

Parker Jewish Institute for Health Care and Rehabilitation

New Hyde Park, New York, United States

Site Status

New York University School of Medicine/Psychiarty

New York, New York, United States

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Columbia University Medical Center

New York, New York, United States

Site Status

Nathan S. Kline Institute for Psychiatric Research

Orangeburg, New York, United States

Site Status

University of Rochester Medical Center, Monroe Community Hospital

Rochester, New York, United States

Site Status

Duke University Medical Center

Durham, North Carolina, United States

Site Status

Clinical Trials of America, Inc

Hickory, North Carolina, United States

Site Status

Raleigh Neurology Associates

Raleigh, North Carolina, United States

Site Status

Neuro-Behavioral Clinical Research, Inc.

Canton, Ohio, United States

Site Status

Ohio State University, Dept. of Neurology

Columbus, Ohio, United States

Site Status

Neurology Specialists, Inc.

Dayton, Ohio, United States

Site Status

Lynn Health Science Institute

Oklahoma City, Oklahoma, United States

Site Status

Red River Medical Research Center, LLC

Oklahoma City, Oklahoma, United States

Site Status

Providence Medical Group-Medford Neurology

Medford, Oregon, United States

Site Status

Summit Research Group, LLC

Portland, Oregon, United States

Site Status

Providence Health Service System, AD Center, Brain Institute

Portland, Oregon, United States

Site Status

Oregon Health and Science University

Portland, Oregon, United States

Site Status

Abington Neurological Associates, Ltd.

Abington, Pennsylvania, United States

Site Status

Lehigh Valley Health Network

Allentown, Pennsylvania, United States

Site Status

The Clinical Trial Center, LLC

Jenkintown, Pennsylvania, United States

Site Status

Drexel University College of Medicine

Philadelphia, Pennsylvania, United States

Site Status

Penn Memory Center

Philadelphia, Pennsylvania, United States

Site Status

Jefferson Hospital for Neuroscience

Philadelphia, Pennsylvania, United States

Site Status

Clinical Trials Research Services, LLC

Pittsburgh, Pennsylvania, United States

Site Status

University of Pittsburgh

Pittsburgh, Pennsylvania, United States

Site Status

Rhode Island Mood and Memory Research Institute

East Providence, Rhode Island, United States

Site Status

Rhode Island Hospital

Providence, Rhode Island, United States

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Butler Hospital

Providence, Rhode Island, United States

Site Status

Medical University of South Carolina

North Charleston, South Carolina, United States

Site Status

Avera Research Institute

Sioux Falls, South Dakota, United States

Site Status

Neurology Clinic, P.C.

Cordova, Tennessee, United States

Site Status

East Tennessee State University

Johnson City, Tennessee, United States

Site Status

Volunteer Research Group

Knoxville, Tennessee, United States

Site Status

Psychiatric Consultants, PC

Nashville, Tennessee, United States

Site Status

Senior Adults Specialty Research (SASR)

Austin, Texas, United States

Site Status

Texas Neurology, PA

Dallas, Texas, United States

Site Status

University of Texas Southwestern Medical Center, Dept. of Neurology

Dallas, Texas, United States

Site Status

InSite Clinical Research

DeSoto, Texas, United States

Site Status

University of North Texas Health Science Center at Fort Worth

Fort Worth, Texas, United States

Site Status

Baylor College of Medicine

Houston, Texas, United States

Site Status

Innovative Clinical Trials

San Antonio, Texas, United States

Site Status

Integra Clinical Research, LLC

San Antonio, Texas, United States

Site Status

Wasatch Clinical Research

Salt Lake City, Utah, United States

Site Status

University of Utah, Dept. of Neurology

Salt Lake City, Utah, United States

Site Status

The Memory Clinic

Bennington, Vermont, United States

Site Status

Fletcher Allen Health Care

Burlington, Vermont, United States

Site Status

Innovative Clinical Research Center

Alexandria, Virginia, United States

Site Status

University of Virginia

Charlottesville, Virginia, United States

Site Status

Alliance Research Group, LLC

Richmond, Virginia, United States

Site Status

University of Washington Veterans Affairs

Seattle, Washington, United States

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Pacific Medical Centers

Seattle, Washington, United States

Site Status

Medical College of Wisconsin, Froedtert Memorial Lutheran Hospital

Milwaukee, Wisconsin, United States

Site Status

Independent Psychiatric Consultants

Waukesha, Wisconsin, United States

Site Status

Landeskrankenhaus- Universitätsklinikum Graz

Graz, Styria, Austria

Site Status

University of Calgary, Foothills Medical Centre

Calgary, Alberta, Canada

Site Status

Medical Arts Health Research Group

Kamloops, British Columbia, Canada

Site Status

Medical Arts Health Research Group

Kelowna, British Columbia, Canada

Site Status

Queens University Memorial Clinics

Kingston, Ontario, Canada

Site Status

Parkwood Hospital

London, Ontario, Canada

Site Status

Bruyere Continuing Care

Ottawa, Ontario, Canada

Site Status

Neurology Research Inc

Toronto, Ontario, Canada

Site Status

Toronto Centre for Memory and Aging

Toronto, Ontario, Canada

Site Status

Ontario Shores Centre for Mental Health Sciences

Whitby, Ontario, Canada

Site Status

Neuro Rive-Sud Memory Clinic

Greenfield Park, Quebec, Canada

Site Status

Hôpital Maisonneuve-Rosemont

Montreal, Quebec, Canada

Site Status

Sir Mortimer B. Davis, Jewish General Hospital

Montreal, Quebec, Canada

Site Status

Diex Research Sherbrooke Inc.

Sherbrooke, Quebec, Canada

Site Status

Douglas Mental Health University Institute

Verdun, Quebec, Canada

Site Status

Countries

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United States Austria Canada

Other Identifiers

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ELN115727-351

Identifier Type: -

Identifier Source: org_study_id