A Study to Evaluate the Efficacy and Safety of DR-103 for the Prevention of Pregnancy

NCT ID: NCT00996580

Last Updated: 2013-06-24

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

3597 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-10-31

Study Completion Date

2011-09-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This is an open-label, single-treatment study. All subjects will receive 12 months of oral contraceptive therapy with DR-103. Study participants will receive physical and gynecological exams, including Pap smear. During the study, all participants will be required to complete a diary.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Pregnancy Prevention

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

DR-103

Four 91-day cycles of the DR-103 regimen:

* 42 days combination therapy of 20 mcg ethinyl estradiol (EE) /150 mcg levonorgestrel (LNG) followed by;
* 21 days combination therapy of 25 mcg EE/150 mcg LNG followed by;
* 21 days combination therapy of 30 mcg EE/150 mcg LNG followed by;
* 7 days of 10 mcg EE.

Group Type EXPERIMENTAL

DR-103

Intervention Type DRUG

One tablet daily.

Four 91-day cycles of the DR-103 regimen:

42 days combination therapy of 20 mcg ethinyl estradiol (EE) /150 mcg levonorgestrel (LNG) followed by; 21 days combination therapy of 25 mcg EE/150 mcg LNG followed by; 21 days combination therapy of 30 mcg EE/150 mcg LNG followed by; 7 days of 10 mcg EE.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

DR-103

One tablet daily.

Four 91-day cycles of the DR-103 regimen:

42 days combination therapy of 20 mcg ethinyl estradiol (EE) /150 mcg levonorgestrel (LNG) followed by; 21 days combination therapy of 25 mcg EE/150 mcg LNG followed by; 21 days combination therapy of 30 mcg EE/150 mcg LNG followed by; 7 days of 10 mcg EE.

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

levonorgestrel/ethinyl estradiol Quartette®

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Sexually active at risk for pregnancy
* Agreement to use study OC therapy as their only method of birth control during the study
* history of regular spontaneous menstrual cycles or withdrawal bleeding episodes
* Others as dictated by FDA-approved protocol

Exclusion Criteria

* Any contraindication to the use of oral contraceptives
* Pregnancy or plans to become pregnant in the next 14 months
* Smoker and age ≥ 35 years
* Others as dictated by FDA-approved protocol
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Teva Women's Health

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Teva Women's Health Research Investigational Site

Montgomery, Alabama, United States

Site Status

Teva Women's Health Research Investigational Site

Phoenix, Arizona, United States

Site Status

Teva Women's Health Research Investigational Site

Phoenix, Arizona, United States

Site Status

Teva Women's Health Research Investigational Site

Tucson, Arizona, United States

Site Status

Teva Women's Health Research Investigational Site

Little Rock, Arkansas, United States

Site Status

Teva Women's Health Research Investigational Site

Anaheim, California, United States

Site Status

Teva Women's Health Research Investigational Site

Irvine, California, United States

Site Status

Teva Women's Health Research Investigational Site

Los Angeles, California, United States

Site Status

Teva Women's Health Research Investigational Site

National City, California, United States

Site Status

Teva Women's Health Research Investigational Site

San Diego, California, United States

Site Status

Teva Women's Health Research Investigational Site

San Diego, California, United States

Site Status

Teva Women's Health Research Investigational Site

San Diego, California, United States

Site Status

Teva Women's Health Research Investigational Site

San Francisco, California, United States

Site Status

Teva Women's Health Research Investigational Site

Torrance, California, United States

Site Status

Teva Women's Health Research Investigational Site

Colorado Springs, Colorado, United States

Site Status

Teva Women's Health Research Investigational Site

Pueblo, Colorado, United States

Site Status

Teva Women's Health Research Investigational Site

Washington D.C., District of Columbia, United States

Site Status

Teva Women's Health Research Investigational Site

Clearwater, Florida, United States

Site Status

Teva Women's Health Research Investigational Site

Jacksonville, Florida, United States

Site Status

Teva Women's Health Research Investigational Site

Leesburg, Florida, United States

Site Status

Teva Women's Health Research Investigational Site

Miami, Florida, United States

Site Status

Teva Women's Health Research Investigational Site

Miami, Florida, United States

Site Status

Teva Women's Health Research Investigational Site

New Port Richey, Florida, United States

Site Status

Teva Women's Health Research Investigational Site

Palm Beach, Florida, United States

Site Status

Teva Women's Health Research Investigational Site

St. Petersburg, Florida, United States

Site Status

Teva Women's Health Research Investigational Site

Tampa, Florida, United States

Site Status

Teva Women's Health Research Investigational Site

West Palm Beach, Florida, United States

Site Status

Teva Women's Health Research Investigational Site

Atlanta, Georgia, United States

Site Status

Teva Women's Health Research Investigational Site

Decatur, Georgia, United States

Site Status

Teva Women's Health Research Investigational Site

Roswell, Georgia, United States

Site Status

Teva Women's Health Research Investigational Site

Sandy Springs, Georgia, United States

Site Status

Teva Women's Health Research Investigational Site

Savannah, Georgia, United States

Site Status

Teva Women's Health Research Investigational Site

Meridian, Idaho, United States

Site Status

Teva Women's Health Research Investigational Site

Champaign, Illinois, United States

Site Status

Teva Women's Health Research Investigational Site

Wichita, Kansas, United States

Site Status

Teva Women's Health Research Investigational Site

Lexington, Kentucky, United States

Site Status

Teva Women's Health Research Investigational Site

Louisville, Kentucky, United States

Site Status

Teva Women's Health Research Investigational Site

Mount Sterling, Kentucky, United States

Site Status

Teva Women's Health Research Investigational Site

Baton Rouge, Louisiana, United States

Site Status

Teva Women's Health Research Investigational Site

Metairie, Louisiana, United States

Site Status

Teva Women's Health Research Investigational Site

Baltimore, Maryland, United States

Site Status

Teva Women's Health Research Investigational Site

Kansas City, Missouri, United States

Site Status

Teva Women's Health Research Investigational Site

St Louis, Missouri, United States

Site Status

Teva Women's Health Research Investigational Site

Lincoln, Nebraska, United States

Site Status

Teva Women's Health Research Investigational Site

Las Vegas, Nevada, United States

Site Status

Teva Women's Health Research Investigational Site

Berlin, New Jersey, United States

Site Status

Teva Women's Health Research Investigational Site

Lawrenceville, New Jersey, United States

Site Status

Teva Women's Health Research Investigational Site

Moorestown, New Jersey, United States

Site Status

Teva Women's Health Research Investigational Site

New Brunswick, New Jersey, United States

Site Status

Teva Women's Health Research Investigational Site

Albuquerque, New Mexico, United States

Site Status

Teva Women's Health Research Investigational Site

Port Jefferson, New York, United States

Site Status

Teva Women's Health Research Investigational Site

Rochester, New York, United States

Site Status

Teva Women's Health Research Investigational Site

Cary, North Carolina, United States

Site Status

Teva Women's Health Research Investigational Site

Charlotte, North Carolina, United States

Site Status

Teva Women's Health Research Investigational Site

New Bern, North Carolina, United States

Site Status

Teva Women's Health Research Investigational Site

Raleigh, North Carolina, United States

Site Status

Teva Women's Health Research Investigational Site

Raleigh, North Carolina, United States

Site Status

Teva Women's Health Research Investigational Site

Salisbury, North Carolina, United States

Site Status

Teva Women's Health Research Investigational Site

Wilmington, North Carolina, United States

Site Status

Teva Women's Health Research Investigational Site

Winston-Salem, North Carolina, United States

Site Status

Teva Women's Health Research Investigational Site

Columbus, Ohio, United States

Site Status

Teva Women's Health Research Investigational Site

Columbus, Ohio, United States

Site Status

Teva Women's Health Research Investigational Site

Edmond, Oklahoma, United States

Site Status

Teva Women's Health Research Investigational Site

Oklahoma City, Oklahoma, United States

Site Status

Teva Women's Health Research Investigational Site

Eugene, Oregon, United States

Site Status

Teva Women's Health Research Investigational Site

Medford, Oregon, United States

Site Status

Teva Women's Health Research Investigational Site

Philadelphia, Pennsylvania, United States

Site Status

Teva Women's Health Research Investigational Site

Pittsburgh, Pennsylvania, United States

Site Status

Teva Women's Health Research Investigational Site

Charleston, South Carolina, United States

Site Status

Teva Women's Health Research Investigational Site

Columbia, South Carolina, United States

Site Status

Teva Women's Health Research Investigational Site

Goose Creek, South Carolina, United States

Site Status

Teva Women's Health Research Investigational Site

Greenville, South Carolina, United States

Site Status

Teva Women's Health Research Investigational Site

Greer, South Carolina, United States

Site Status

Teva Women's Health Research Investigational Site

Hilton Head Island, South Carolina, United States

Site Status

Teva Women's Health Research Investigational Site

Bristol, Tennessee, United States

Site Status

Teva Women's Health Research Investigational Site

Jackson, Tennessee, United States

Site Status

Teva Women's Health Research Investigational Site

Knoxville, Tennessee, United States

Site Status

Teva Women's Health Research Investigational Site

Memphis, Tennessee, United States

Site Status

Teva Women's Health Research Investigational Site

Nashville, Tennessee, United States

Site Status

Teva Women's Health Research Investigational Site

Austin, Texas, United States

Site Status

Teva Women's Health Research Investigational Site

Dallas, Texas, United States

Site Status

Teva Women's Health Research Investigational Site

Dallas, Texas, United States

Site Status

Teva Women's Health Research Investigational Site

Fort Worth, Texas, United States

Site Status

Teva Women's Health Research Investigational Site

Houston, Texas, United States

Site Status

Teva Women's Health Research Investigational Site

San Antonio, Texas, United States

Site Status

Teva Women's Health Research Investigational Site

Waco, Texas, United States

Site Status

Teva Women's Health Research Investigational Site

Salt Lake City, Utah, United States

Site Status

Teva Women's Health Research Investigational Site

Arlington, Virginia, United States

Site Status

Teva Women's Health Research Investigational Site

Newport News, Virginia, United States

Site Status

Teva Women's Health Research Investigational Site

Norfolk, Virginia, United States

Site Status

Teva Women's Health Research Investigational Site

Norfolk, Virginia, United States

Site Status

Teva Women's Health Research Investigational Site

Richmond, Virginia, United States

Site Status

Teva Women's Health Research Investigational Site

Seattle, Washington, United States

Site Status

Teva Women's Health Research Investigational Site

Tacoma, Washington, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

References

Explore related publications, articles, or registry entries linked to this study.

Poindexter A, Reape KZ, Hait H. Efficacy and safety of a 28-day oral contraceptive with 7 days of low-dose estrogen in place of placebo. Contraception. 2008 Aug;78(2):113-9. doi: 10.1016/j.contraception.2008.04.001. Epub 2008 Jun 2.

Reference Type RESULT
PMID: 18672111 (View on PubMed)

Portman DJ, Kaunitz AM, Howard B, Weiss H, Hsieh J, Ricciotti N. Efficacy and safety of an ascending-dose, extended-regimen levonorgestrel/ethinyl estradiol combined oral contraceptive. Contraception. 2014 Apr;89(4):299-306. doi: 10.1016/j.contraception.2014.01.013. Epub 2014 Jan 29.

Reference Type DERIVED
PMID: 24576794 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

DR-103-301

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Long-Acting Reversible Contraception
NCT01299116 COMPLETED PHASE4