A Trial to Evaluate DR-2021 in Women With Secondary Amenorrhea

NCT ID: NCT00196391

Last Updated: 2014-07-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

180 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-09-30

Study Completion Date

2007-04-30

Brief Summary

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This is a multicenter trial to compare the effectiveness of 4 doses of DR-2021 with placebo and oral micronized progesterone in inducing withdrawal bleeding in women with secondary amenorrhea.

Detailed Description

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In this multicenter trial patients will be randomized to receive DR-2021, oral micronized progesterone, and placebo to evaluate the effects on withdrawal bleeding in women with secondary amenorrhea. Patients will be treated for 10 days and study participation will be approximately 24 days. Patients will undergo a physical exam including a pelvic and breast exam. Patients will be required to complete bleeding and spotting information daily in a diary.

Conditions

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Amenorrhea

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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1

Group Type EXPERIMENTAL

DR-2021a

Intervention Type DRUG

1 capsule daily for 10 days

2

Group Type EXPERIMENTAL

DR-2021b

Intervention Type DRUG

1 capsule daily for 10 days

3

Group Type EXPERIMENTAL

DR-2021c

Intervention Type DRUG

1 capsule daily for 10 days

4

Group Type EXPERIMENTAL

DR-2021d

Intervention Type DRUG

1 capsule daily for 10 days

5

Group Type EXPERIMENTAL

DR-2021e

Intervention Type DRUG

1 capsule daily for 10 days

6

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type OTHER

1 matching placebo capsule for 10 days

Interventions

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DR-2021a

1 capsule daily for 10 days

Intervention Type DRUG

DR-2021b

1 capsule daily for 10 days

Intervention Type DRUG

DR-2021c

1 capsule daily for 10 days

Intervention Type DRUG

DR-2021d

1 capsule daily for 10 days

Intervention Type DRUG

DR-2021e

1 capsule daily for 10 days

Intervention Type DRUG

Placebo

1 matching placebo capsule for 10 days

Intervention Type OTHER

Other Intervention Names

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Micronized progesterone Micronized Progesterone Micronized Progesterone Micronized Progesterone

Eligibility Criteria

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Inclusion Criteria

* Not pregnant
* Secondary amenorrhea or oligomenorrhea of at least 50 days duration
* Not currently on any hormonal medication
* Not at risk of pregnancy or willing to use a non-hormonal method of birth control during the study (ie, condom)

Exclusion Criteria

* Use an injectable or implantable estrogens, progestins, or androgens within the last 6 months
* Use of any hormonal birth control within the last 3 months
* Any contraindication to the use of progestins
Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Duramed Research

INDUSTRY

Sponsor Role lead

Responsible Party

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Duramed Research, Inc.

Principal Investigators

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Duramed Protocol Chair

Role: STUDY_CHAIR

Duramed Research, Inc.

Locations

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Duramed Investigational Site

Mobile, Alabama, United States

Site Status

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Phoenix, Arizona, United States

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Tucson, Arizona, United States

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Carmichael, California, United States

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San Diego, California, United States

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San Diego, California, United States

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Colorado Springs, Colorado, United States

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Pueblo, Colorado, United States

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Gainesville, Florida, United States

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Leesburg, Florida, United States

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Miami, Florida, United States

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Atlanta, Georgia, United States

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Dawsonville, Georgia, United States

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Douglasville, Georgia, United States

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Laurel, Maryland, United States

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St Louis, Missouri, United States

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Alliance, Nebraska, United States

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Lawrenceville, New Jersey, United States

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Medford, Oregon, United States

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Pittsburgh, Pennsylvania, United States

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Willow Grove, Pennsylvania, United States

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Columbia, South Carolina, United States

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Memphis, Tennessee, United States

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Dallas, Texas, United States

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Houston, Texas, United States

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Houston, Texas, United States

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Newport News, Virginia, United States

Site Status

Countries

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United States

Other Identifiers

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DR-MPG-201

Identifier Type: -

Identifier Source: org_study_id

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