A Study to Evaluate Ovarian Follicular Activity and Hormone Levels for DR-102 Compared to Two 28-Day Oral Contraceptives

NCT ID: NCT01291004

Last Updated: 2021-12-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

206 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-01-31

Study Completion Date

2012-03-31

Brief Summary

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This study is being conducted to evaluate the impact of a 28-day oral contraceptive compared to two 28-day oral contraceptive regimens containing different synthetic progestins on ovarian follicular activity and hormone levels in healthy women.

Detailed Description

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Conditions

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Follicle Development Ovarian Follicle Follicle Count Follicle Size Oral Contraceptive

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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28-day Desogestrel Oral Contraceptive

Group Type EXPERIMENTAL

Desogestrel/ethinyl estradiol and ethinyl estradiol

Intervention Type DRUG

Desogestrel/ethinyl estradiol 0.15/0.02 mg and ethinyl estradiol 0.01 mg tablet

28-day Drospirenone Oral Contraceptive

Group Type ACTIVE_COMPARATOR

28-day drospirenone oral contraceptive

Intervention Type DRUG

Drospirenone/ethinyl estradiol 0.3/0.02 mg

28-day Levonorgestrel Oral Contraceptive

Group Type ACTIVE_COMPARATOR

28-day levonorgestrel oral contraceptive

Intervention Type DRUG

Levonorgestrel/ethinyl estradiol 0.1/0.02 mg

Interventions

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Desogestrel/ethinyl estradiol and ethinyl estradiol

Desogestrel/ethinyl estradiol 0.15/0.02 mg and ethinyl estradiol 0.01 mg tablet

Intervention Type DRUG

28-day drospirenone oral contraceptive

Drospirenone/ethinyl estradiol 0.3/0.02 mg

Intervention Type DRUG

28-day levonorgestrel oral contraceptive

Levonorgestrel/ethinyl estradiol 0.1/0.02 mg

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Premenopausal, non-pregnant, non-lactating women age 18-35 years old
* Body Mass Index (BMI) ≥18 kg/m² and \<30 kg/m²
* Regular spontaneous menstrual cycle
* Others as dictated by Food and Drug Administration (FDA)-approved protocol

Exclusion Criteria

* Any condition which contraindicates the use of combination oral contraceptives
* Known thrombophlebitis or thromboembolic disorders; known or suspected clotting disorders; thrombogenic valvulopathies or rhythm disorders
* Migraine headaches with focal, neurological symptoms
* Others as dictated by FDA-approved protocol
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Teva Branded Pharmaceutical Products R&D, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Teva Women's Health Research Protocol Chair

Role: STUDY_CHAIR

Teva Branded Pharmaceutical Products R&D, Inc.

Locations

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Teva Investigational Site 10119

Philadelphia, Pennsylvania, United States

Site Status

Teva Investigational Site 10118

Seattle, Washington, United States

Site Status

Countries

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United States

Other Identifiers

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DSG-OI-101

Identifier Type: -

Identifier Source: org_study_id