This is a Post Approval Study of Coaptite® in the Treatment of Female Urinary Incontinence

NCT ID: NCT00996489

Last Updated: 2019-07-23

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

459 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-01-08

Study Completion Date

2015-11-02

Brief Summary

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This is a post approval study of Coaptite® in the treatment of female urinary incontinence.

Detailed Description

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Conditions

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Female Stress Urinary Incontinence Due to Intrinsic Sphincter Deficiency

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Coaptite

Group Type EXPERIMENTAL

Coaptite®

Intervention Type DEVICE

Calcium hydroxylapatite particles suspended in an aqueous based gel carrier

Interventions

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Coaptite®

Calcium hydroxylapatite particles suspended in an aqueous based gel carrier

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Has female stress urinary incontinence that is due to intrinsic sphincter deficiency
* Has a baseline pad weight of greater than or equal to 50 grams
* Has viable mucosal lining at likely site of injection (bladder neck)
* Is at least 18 years of age
* Understands and accepts the obligation and is logistically able to present for all scheduled study visits
* Signs written informed consent

Exclusion Criteria

* Has had a previous treatment for urinary incontinence with a urethral bulking agent other than Coaptite® or collagen
* Has detrusor instability
* Has bladder neuropathy
* Has nocturnal enuresis (bed wetting)
* Has Grade II or III prolapsed bladder
* Has overflow or functional incontinence
* Has significant history of urinary tract infections without resolution
* Has current or acute conditions of cystitis or urethritis
* Has history of significant pelvic irradiation
* Is pregnant or lactating
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Merz North America, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Wetumpka, Alabama, United States

Site Status

Surprise, Arizona, United States

Site Status

Encinitas, California, United States

Site Status

Los Angeles, California, United States

Site Status

Oceanside, California, United States

Site Status

Orange, California, United States

Site Status

Templeton, California, United States

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Celebration, Florida, United States

Site Status

Orlando, Florida, United States

Site Status

St. Petersburg, Florida, United States

Site Status

Berwyn, Illinois, United States

Site Status

Evanston, Illinois, United States

Site Status

Overland Park, Kansas, United States

Site Status

Grand Rapids, Michigan, United States

Site Status

St Louis, Missouri, United States

Site Status

Rochester, New York, United States

Site Status

Akron, Ohio, United States

Site Status

Houston, Texas, United States

Site Status

Temple, Texas, United States

Site Status

Mountlake Terrace, Washington, United States

Site Status

Countries

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United States

Other Identifiers

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P1005185

Identifier Type: -

Identifier Source: org_study_id

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