AT9283 in Children and Adolescents With Relapsed and Refractory Solid Tumors

NCT ID: NCT00985868

Last Updated: 2019-11-29

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1
• Total Enrollment: 33 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2009-09-30
• Study Completion Date: 2019-11-20

Brief Summary

RATIONALE: AT9283 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

PURPOSE: This phase I trial is studying the side effects and best dose of AT9283 in children and adolescents with relapsed and refractory solid tumors.

Detailed Description

OBJECTIVES:

Primary

• To evaluate the safety and tolerability of Aurora kinase inhibitor AT9283 by characterizing the dose-limiting toxicities in children and adolescents with relapsed and refractory solid tumors.
• To determine the maximum-tolerated dose of this regimen in these patients.

Secondary

• To determine the pharmacokinetic parameters of this regimen in these patients.
• To demonstrate the pharmacodynamic (PD) activity of this regimen in these patients by studying its effects in surrogate tissue.
• To assess preliminary evidence of activity of this regimen by using appropriate objective tumor measurements in these patients.

Tertiary

• To demonstrate the PD activity of this regimen in these patients by studying its effects in both surrogate and tumor tissue (skin punch, bone marrow, and tumor biopsies).

OUTLINE: This is a multicenter, dose-escalation study.

Patients receive Aurora kinase inhibitor AT9283 IV over 72 hours on days 1-3. Treatment repeats every 21 days for up to 6 courses in the absence of disease progression or unacceptable toxicity.If a patient is benefiting from treatment with AT9283 (i.e. has stable or responding disease as measured by RECIST) and the benefit risk balance is considered acceptable then further treatment may be given.

Blood and skin tissue samples are collected at baseline and periodically during treatment for pharmacokinetic studies and pharmacodynamic and biomarker (M30, M65, pHH53, p53, PCNA and Ki67) analysis by IHC and ELISA assays.

After completion of study therapy, patients are followed up periodically.

Peer Reviewed and Funded or Endorsed by Cancer Research UK.

Conditions

Unspecified Childhood Solid Tumor, Protocol Specific

Study Design

• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Interventions

multikinase inhibitor AT9283

Intervention Type: DRUG

enzyme-linked immunosorbent assay

Intervention Type: OTHER

immunohistochemistry staining method

Intervention Type: OTHER

laboratory biomarker analysis

Intervention Type: OTHER

pharmacological study

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

DISEASE CHARACTERISTICS:

• Histologically confirmed solid tumor meeting 1 of the following criteria:

• Refractory to conventional treatment
• Disease for which no conventional therapy exists
• Patients with CNS tumors must be on a stable or decreasing dose of dexamethasone for ≥ 1 week before study entry

PATIENT CHARACTERISTICS:

• WHO performance status (PS) 0-2 OR Lansky Play PS 70-100% (> 50% is acceptable if it is due to a stable neurological deficit or CNS tumor)
• Life expectancy ≥ 12 weeks
• ANC ≥ 1,000/mm^3
• Platelet count ≥ 100,000/mm^3
• Hemoglobin ≥ 9.0 g/dL
• Serum bilirubin < 1.5 times upper limit of normal (ULN)
• Creatinine kinase normal
• ALT or AST < 2.5 times ULN (≤ 5 times ULN if due to tumor)
• Creatinine clearance/EDTA-measured GFR ≥ 60 mL/min
• Sufficient blood volume to undergo the blood-sampling regimen specified by the protocol that, in the opinion of the investigator, will not jeopardize patient's safety
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use 2 methods of effective contraception 4 weeks before, during, and for 6 months after completion of study therapy
• Not at high medical risk because of non-malignant systemic disease, including active uncontrolled infection
• Not known to be serologically positive for hepatitis B or C or HIV
• Fractional shortening of > 29% on echocardiogram
• LVEF ≥ 50%
• No history of allergy or auto-immune disease
• No congenital heart disease
• No other condition that, in the investigator's opinion, would not make the patient a good candidate for the clinical trial

PRIOR CONCURRENT THERAPY:

• See Disease Characteristics
• Recovered from prior therapy
• More than 4 weeks since prior radiotherapy (except for palliative reasons), endocrine therapy, immunotherapy, or chemotherapy (6 weeks for investigational medicinal products, 2 weeks for vincristine)
• More than 3 months since prior autologous stem cell transplantation
• No prior allogenic bone marrow transplantation
• No prior extensive radiotherapy to > 25% of bone marrow
• No prior Aurora kinase inhibitor
• No prior major thoracic or abdominal surgery from which the patient has not yet recovered
• No prior or concurrent participation in another interventional clinical trial

• Participation in an observational study allowed
• No other concurrent anticancer therapy or investigational drugs

• Minimum Eligible Age: 2 Years
• Maximum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Cancer Research UK

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Darren Hargrave, MD

Role: PRINCIPAL_INVESTIGATOR

Great Ormond Street Hospital for Children NHS Foundation Trust

Locations

Birmingham Children's Hospital

Birmingham, England, United Kingdom

Leeds General Infirmary

Leeds, England, United Kingdom

Royal Manchester Children's Hospital

Manchester, England, United Kingdom

Great North Children's Hospital, Royal Victoria Infirmary

Newcastle upon Tyne, England, United Kingdom

Royal Marsden - Surrey

Sutton, England, United Kingdom

Countries

United Kingdom

Other Identifiers

UKM-ICRF-CR0708-11

Identifier Type: -

Identifier Source: secondary_id

CRUK-CR0708-11

Identifier Type: -

Identifier Source: secondary_id

EUDRACT-2008-005542-23

Identifier Type: -

Identifier Source: secondary_id

EU-20980

Identifier Type: -

Identifier Source: secondary_id

CDR0000653387

Identifier Type: -

Identifier Source: org_study_id