Dapagliflozin DPPIV Inhibitor add-on Study

NCT ID: NCT00984867

Last Updated: 2014-06-13

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

833 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-10-31

Study Completion Date

2011-09-30

Brief Summary

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This study aims to investigate how dapagliflozin can control blood sugar in patients with type 2 diabetes when added to existing treatments (sitagliptin alone or in combination with metformin). The effect of dapagliflozin on weight and blood pressure will also be studied.

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Detailed Description

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Conditions

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Type 2 Diabetes

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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1

Dapagliflozin 10 mg tablet

Group Type ACTIVE_COMPARATOR

Dapagliflozin

Intervention Type DRUG

10 mg tablet, oral, once daily, 48 weeks

2

Matching placebo tablet

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Matching placebo tablet

Interventions

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Dapagliflozin

10 mg tablet, oral, once daily, 48 weeks

Intervention Type DRUG

Placebo

Matching placebo tablet

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients with type 2 diabetes
* Patients who are not receiving treatment , or those who currently receive metformin, sitagliptin or vildagliptin or the combination of these
* Patients will be screened by a blood test and only those who need additional therapy can be enrolled

Exclusion Criteria

* Patients with type 1 diabetes
* Patients with very poorly controlled diabetes
* Any clinically significant illness, which in the judgement of the investigator would compromise the patient's safety or successful participation in the clinical study
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Bristol-Myers Squibb

INDUSTRY

Sponsor Role collaborator

AstraZeneca

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Serge Jabbour, MD

Role: PRINCIPAL_INVESTIGATOR

Thomas Jefferson University, Philadelphia

Locations

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Research Site

Huntsville, Alabama, United States

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Ozark, Alabama, United States

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Anaheim, California, United States

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Chula Vista, California, United States

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Greenbrae, California, United States

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Laguna Hills, California, United States

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Los Angeles, California, United States

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Riverside, California, United States

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West Hills, California, United States

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Boca Raton, Florida, United States

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DeLand, Florida, United States

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Jacksonville, Florida, United States

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Longwood, Florida, United States

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Miami, Florida, United States

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Port Orange, Florida, United States

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West Palm Beach, Florida, United States

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Stone Mountain, Georgia, United States

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Wichita, Kansas, United States

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Lake Charles, Louisiana, United States

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Edina, Minnesota, United States

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St Louis, Missouri, United States

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Las Vegas, Nevada, United States

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Pahrump, Nevada, United States

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Staten Island, New York, United States

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Wilmington, North Carolina, United States

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Cincinnati, Ohio, United States

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Columbus, Ohio, United States

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Dayton, Ohio, United States

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Oklahoma City, Oklahoma, United States

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Medord, Oregon, United States

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Lancaster, Pennsylvania, United States

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Philadelphia, Pennsylvania, United States

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Mt. Pleasant, South Carolina, United States

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Myrtle Beach, South Carolina, United States

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Simpsonville, South Carolina, United States

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Bristol, Tennessee, United States

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Corpus Christi, Texas, United States

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Dallas, Texas, United States

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North Richland Hills, Texas, United States

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San Antonio, Texas, United States

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Salt Lake City, Utah, United States

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Burke, Virginia, United States

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Manassas, Virginia, United States

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Richmond, Virginia, United States

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Lakewood, Washington, United States

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Berazategui, Buenos Aires, Argentina

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La Plata, Buenos Aires, Argentina

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Lanús, Buenos Aires, Argentina

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Mar del Plata, Buenos Aires, Argentina

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Morón, Buenos Aires, Argentina

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Buenos Aires, Buenos Aires F.D., Argentina

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Caba, Buenos Aires F.D., Argentina

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Córdoba, Córdoba Province, Argentina

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Salta, Salta Province, Argentina

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Santa Fe, Santa Fe Province, Argentina

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Bad Nauheim, , Germany

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Berlin, , Germany

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Dresden, , Germany

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Hamburg, , Germany

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Meissen, , Germany

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Münster, , Germany

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Pirna, , Germany

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Wangen, , Germany

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Guadalajara, Jalisco, Mexico

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Mexico City, Mexico City, Mexico

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Ciechocinek, , Poland

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Czechowice-Dziedzice, , Poland

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Gdansk, , Poland

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Gniewkowo, , Poland

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Krakow, , Poland

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Krotoszyn, , Poland

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Mrągowo, , Poland

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Poznan, , Poland

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Sopot, , Poland

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Torun, , Poland

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Zabrze, , Poland

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Łęczyca, , Poland

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Bolton, Lancs, United Kingdom

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Burbage, Leicester, United Kingdom

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Sunbury-on-Thames, Middlesex, United Kingdom

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Wansford, Peterborough, United Kingdom

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Ecclesfield, Sheffield, United Kingdom

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Addlestone, Surrey, United Kingdom

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Bath, , United Kingdom

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Belfast, , United Kingdom

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Blackpool, , United Kingdom

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Coventry, , United Kingdom

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Harrow, , United Kingdom

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Countries

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United States Argentina Germany Mexico Poland United Kingdom

References

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Jabbour SA, Hardy E, Sugg J, Parikh S; Study 10 Group. Dapagliflozin is effective as add-on therapy to sitagliptin with or without metformin: a 24-week, multicenter, randomized, double-blind, placebo-controlled study. Diabetes Care. 2014;37(3):740-50. doi: 10.2337/dc13-0467. Epub 2013 Oct 21.

Reference Type RESULT
PMID: 24144654 (View on PubMed)

Natale P, Tunnicliffe DJ, Toyama T, Palmer SC, Saglimbene VM, Ruospo M, Gargano L, Stallone G, Gesualdo L, Strippoli GF. Sodium-glucose co-transporter protein 2 (SGLT2) inhibitors for people with chronic kidney disease and diabetes. Cochrane Database Syst Rev. 2024 May 21;5(5):CD015588. doi: 10.1002/14651858.CD015588.pub2.

Reference Type DERIVED
PMID: 38770818 (View on PubMed)

Related Links

Other Identifiers

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D1690C00010

Identifier Type: -

Identifier Source: org_study_id

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