The Renin-Aldosterone Axis in Postural Tachycardia Syndrome

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

28 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-04-30

Study Completion Date

2012-12-31

Brief Summary

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The purpose of this study is to determine the role of the renin-angiotensin-aldosterone in the pathophysiology of postural tachycardia syndrome, and to provide an insight about the disease process in this disorder.

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Detailed Description

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Conditions

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Postural Orthostatic Tachycardia Syndrome (POTS)

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Control

Healthy controls

Group Type EXPERIMENTAL

Angiotensin II

Intervention Type DRUG

Angiotensin II infusion for 1 hour

Postural Tachycardia Syndrome

Patients with Postural Tachycardia Syndrome

Group Type EXPERIMENTAL

Angiotensin II

Intervention Type DRUG

Angiotensin II infusion for 1 hour

Interventions

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Angiotensin II

Angiotensin II infusion for 1 hour

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of postural tachycardia syndrome by the Vanderbilt Autonomic Dysfunction Center criteria
* Age between 18-64 years
* Male or females are eligible
* Able and willing to provide informed consent
* Healthy control subjects with no major medical problem (including postural tachycardia syndrome), free of medications during the study

Exclusion Criteria

* Overt cause of postural tachycardia e.g., dehydration
* Inability to give or withdraw informed consent
* Pregnancy
* Hypertension (BP \> 140/90)
* Significant co-morbid condition
* Other factors which in the investigator's opinion would prevent the subject from completing the protocol

Minimum Eligible Age

18 Years

Maximum Eligible Age

64 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes