Study of Prevalence and Clinical Phenotype in Patients With Glucocorticoid-Remediable Aldosteronism
NCT ID: NCT00004354
Last Updated: 2005-06-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
OBSERVATIONAL
1999-06-30
Brief Summary
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II. Investigate other factors regulating blood pressure in GRA (environmental, genetically determined factors).
III. Investigate renal and hormonal mechanisms regulating potassium homeostasis in GRA.
IV. Describe clinical phenotype of GRA patients. V. Prospectively screen GRA-affected patients with MRI angiography for intracranial aneurysm.
Detailed Description
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Patients are screened for high blood pressure, suppressed plasma renin activity level, and low potassium levels. Urine is collected for a 24 hour period. Blood specimen is collected for molecular biologic evaluation for the presence of the chimeric gene diagnostic of GRA. Any history of cardiovascular events is recorded.
Conditions
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Eligibility Criteria
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Inclusion Criteria
--Disease Characteristics-- Diagnosed glucocorticoid-remediable aldosteronism (GRA) with hypertension Hypokalemia is variably seen Blood pressure variably elevated Elevated level of aldosterone Low level of plasma renin activity
0 Years
ALL
No
Sponsors
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Brigham and Women's Hospital
OTHER
National Center for Research Resources (NCRR)
NIH
Principal Investigators
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Robert G. Dluhy
Role: STUDY_CHAIR
Brigham and Women's Hospital
Locations
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Brigham and Women's Hospital
Boston, Massachusetts, United States
Countries
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Other Identifiers
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BWH-91328603
Identifier Type: -
Identifier Source: secondary_id
199/11917
Identifier Type: -
Identifier Source: org_study_id