Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ACTIVE_NOT_RECRUITING
NA
800 participants
INTERVENTIONAL
2004-03-31
2026-10-31
Brief Summary
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1. Examining subjective and objective response differences to alcohol and other common substances in a sample of adults with varying consumption patterns.
2. Determining whether response to alcohol and other substances is predictive of future consumption patterns through longitudinal follow-up interviews.
3. Examining the relationship between responses to alcohol and other substances at baseline and re-examination testing to evaluate if consumption patterns moderate this relationship.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
SCREENING
DOUBLE
Study Groups
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Beverage with Heavy Alcohol Dose
Beverage containing 0.8 g/kg alcohol
Ethanol
Beverage containing 0.8 g/kg ethanol, 0.4 g/kg ethanol
Beverage with Low Alcohol Dose
Beverage containing 0.4 g/kg alcohol
Ethanol
Beverage containing 0.8 g/kg ethanol, 0.4 g/kg ethanol
Beverage with No alcohol (Placebo)
Beverage containing 0.0 g/kg alcohol to act as placebo
Placebo
Beverage containing 0.0 g/kg alcohol to act as placebo
Beverage with Diphenhydramine
Beverage containing 1.5 standard dose of Diphenhydramine (Benadryl)
Diphenhydramine
Beverage containing dose equivalent to 1.5 standard doses of Diphenhydramine (Benadryl)
Beverage with Caffeine
Beverage containing the equivalent of 1.5 times participant's average caffeine consumption
Caffeine
Beverage containing the equivalent of 1.5 times the participant's daily caffeine intake
Beverage in Natural Environment
Participant consumes alcohol containing beverages or non-alcohol beverages in natural environment
No interventions assigned to this group
Interventions
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Ethanol
Beverage containing 0.8 g/kg ethanol, 0.4 g/kg ethanol
Placebo
Beverage containing 0.0 g/kg alcohol to act as placebo
Diphenhydramine
Beverage containing dose equivalent to 1.5 standard doses of Diphenhydramine (Benadryl)
Caffeine
Beverage containing the equivalent of 1.5 times the participant's daily caffeine intake
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Weigh between 110-210 lbs
* Drink alcohol at least once weekly with weekly "binge" drinking episodes
* Available to complete in-person screening and 2, 4 hour experimental sessions at the University of Chicago
* Available by phone, mail, or Internet for follow-up interviews for at least 2 years following sessions
Exclusion Criteria
21 Years
65 Years
ALL
No
Sponsors
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National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
University of Chicago
OTHER
Responsible Party
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Principal Investigators
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Andrea C King, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Chicago
Locations
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Clinical Addictions Research Laboratory
Chicago, Illinois, United States
Countries
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References
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King AC, Byars JA. Alcohol-induced performance impairment in heavy episodic and light social drinkers. J Stud Alcohol. 2004 Jan;65(1):27-36. doi: 10.15288/jsa.2004.65.27.
King AC, Houle T, de Wit H, Holdstock L, Schuster A. Biphasic alcohol response differs in heavy versus light drinkers. Alcohol Clin Exp Res. 2002 Jun;26(6):827-35.
Rueger SY, McNamara PJ, King AC. Expanding the utility of the Biphasic Alcohol Effects Scale (BAES) and initial psychometric support for the Brief-BAES (B-BAES). Alcohol Clin Exp Res. 2009 May;33(5):916-24. doi: 10.1111/j.1530-0277.2009.00914.x. Epub 2009 Mar 11.
Epstein AM, Sher TG, Young MA, King AC. Tobacco chippers show robust increases in smoking urge after alcohol consumption. Psychopharmacology (Berl). 2007 Feb;190(3):321-9. doi: 10.1007/s00213-006-0438-8. Epub 2006 Jun 28.
Brumback T, Cao D, King A. Effects of alcohol on psychomotor performance and perceived impairment in heavy binge social drinkers. Drug Alcohol Depend. 2007 Nov 2;91(1):10-7. doi: 10.1016/j.drugalcdep.2007.04.013. Epub 2007 Jun 8.
King A, Epstein A, Conrad M, McNamara P, Cao D. Sex differences in the relationship between alcohol-associated smoking urge and behavior: a pilot study. Am J Addict. 2008 Sep-Oct;17(5):347-53. doi: 10.1080/10550490802268140.
King AC, Epstein AM. Alcohol dose-dependent increases in smoking urge in light smokers. Alcohol Clin Exp Res. 2005 Apr;29(4):547-52. doi: 10.1097/01.alc.0000158839.65251.fe.
King A, Vena A, Hasin DS, deWit H, O'Connor SJ, Cao D. Subjective Responses to Alcohol in the Development and Maintenance of Alcohol Use Disorder. Am J Psychiatry. 2021 Jun;178(6):560-571. doi: 10.1176/appi.ajp.2020.20030247. Epub 2021 Jan 5.
King AC, Cao D, deWit H, O'Connor SJ, Hasin DS. The role of alcohol response phenotypes in the risk for alcohol use disorder. BJPsych Open. 2019 Apr 22;5(3):e38. doi: 10.1192/bjo.2019.18.
King AC, Hasin D, O'Connor SJ, McNamara PJ, Cao D. A Prospective 5-Year Re-examination of Alcohol Response in Heavy Drinkers Progressing in Alcohol Use Disorder. Biol Psychiatry. 2016 Mar 15;79(6):489-98. doi: 10.1016/j.biopsych.2015.05.007. Epub 2015 May 14.
King AC, McNamara PJ, Hasin DS, Cao D. Alcohol challenge responses predict future alcohol use disorder symptoms: a 6-year prospective study. Biol Psychiatry. 2014 May 15;75(10):798-806. doi: 10.1016/j.biopsych.2013.08.001. Epub 2013 Oct 2.
King AC, de Wit H, McNamara PJ, Cao D. Rewarding, stimulant, and sedative alcohol responses and relationship to future binge drinking. Arch Gen Psychiatry. 2011 Apr;68(4):389-99. doi: 10.1001/archgenpsychiatry.2011.26.
Related Links
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Study Website
Other Identifiers
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12119a
Identifier Type: -
Identifier Source: org_study_id
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