Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE4
200 participants
INTERVENTIONAL
2009-08-31
2018-06-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
QUADRUPLE
Study Groups
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esmolol
the study group will receive esmolol (1-3 mg/kg)
Esmolol
esmolol (1-3 mg/kg) during cardiac surgery
normosaline
normosaline (same ml of the study drug)
Placebo
normosaline (same ml of the study drug)
Interventions
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Esmolol
esmolol (1-3 mg/kg) during cardiac surgery
Placebo
normosaline (same ml of the study drug)
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* written informed consent
* age \>18 years
Exclusion Criteria
* inclusion in other randomized studies
* esmolol administration in the previous 30 days
* emergency operation
18 Years
ALL
No
Sponsors
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Università Vita-Salute San Raffaele
OTHER
Responsible Party
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Giovanni Landoni
MD
Locations
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Vita-Salute University
Milan, , Italy
Countries
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References
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Zangrillo A, Turi S, Crescenzi G, Oriani A, Distaso F, Monaco F, Bignami E, Landoni G. Esmolol reduces perioperative ischemia in cardiac surgery: a meta-analysis of randomized controlled studies. J Cardiothorac Vasc Anesth. 2009 Oct;23(5):625-32. doi: 10.1053/j.jvca.2009.01.003. Epub 2009 Mar 18.
Crescenzi G, Rosica C, Marino G, Serini SM, Covello RD, Landoni G, Zangrillo A. The use of esmolol to treat systolic anterior motion of the mitral valve after mitral valve repair. Eur J Anaesthesiol. 2008 Apr;25(4):342-3. doi: 10.1017/S0265021507002876. No abstract available.
Landoni G, Zambon M, Zangrillo A. Reducing perioperative myocardial infarction with anesthetic drugs and techniques. Curr Drug Targets. 2009 Sep;10(9):858-62. doi: 10.2174/138945009789108837. Epub 2009 Sep 1.
Crescenzi G, Landoni G, Zangrillo A, Guarracino F, Rosica C, La Canna G, Alfieri O. Management and decision-making strategy for systolic anterior motion after mitral valve repair. J Thorac Cardiovasc Surg. 2009 Feb;137(2):320-5. doi: 10.1016/j.jtcvs.2008.08.018.
Other Identifiers
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GO/URC/ER/mm 459/DG
Identifier Type: -
Identifier Source: org_study_id
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