Study to Evaluate Safety and Efficacy of Dutogliptin in Type 2 Diabetes Mellitus Subjects With Moderate and Severe Renal Impairment

NCT ID: NCT00958269

Last Updated: 2010-02-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE3

Total Enrollment

360 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-08-31

Study Completion Date

2011-11-30

Brief Summary

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The purpose of this study is to assess the safety and tolerability of dutogliptin in Type 2 diabetic subjects with moderate or severe renal impairment.

Detailed Description

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Conditions

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Type 2 Diabetes Mellitus Renal Impairment

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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dutogliptin (double-blind, placebo-controlled period)

weeks 1-26

Group Type EXPERIMENTAL

dutogliptin

Intervention Type DRUG

100 mg QD

dutogliptin

Intervention Type DRUG

200 mg QD

dutogliptin (single-blind, active-controlled period)

weeks 27-52

Group Type EXPERIMENTAL

dutogliptin

Intervention Type DRUG

100 mg QD

dutogliptin

Intervention Type DRUG

200 mg QD

placebo (double-blind, placebo-controlled period)

weeks 1-26

Group Type PLACEBO_COMPARATOR

placebo

Intervention Type DRUG

placebo (single-blind, active-controlled period)

weeks 27-52

Group Type PLACEBO_COMPARATOR

placebo

Intervention Type DRUG

sitagliptin (single-blind, active-controlled period)

weeks 27-52

Group Type ACTIVE_COMPARATOR

sitagliptin

Intervention Type DRUG

25 mg QD

sitagliptin

Intervention Type DRUG

50 mg QD

Interventions

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dutogliptin

100 mg QD

Intervention Type DRUG

dutogliptin

200 mg QD

Intervention Type DRUG

placebo

Intervention Type DRUG

sitagliptin

25 mg QD

Intervention Type DRUG

sitagliptin

50 mg QD

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Type 2 diabetes mellitus
* Renal impairment (moderate and severe)
* Currently on stable doses of background medication of SU, TZD, acarbose, meglitinide, insulin or any combination thereof, or on no antidiabetic drugs at all
* HbA1c 7.0% - 10.5%, inclusive
* Male or female subjects between the ages of 18 and 85 years, inclusive.

Exclusion Criteria

* Type 1 diabetes mellitus or history of diabetic ketoacidosis, mature onset diabetes of the young (MODY)
* Kidney transplant
Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Forest Laboratories

INDUSTRY

Sponsor Role collaborator

Phenomix

INDUSTRY

Sponsor Role lead

Responsible Party

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Phenomix Corporation

Locations

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Phenomix Investigational Site 115

Tempe, Arizona, United States

Site Status

Phenomix Investigational Site 121

Long Beach, California, United States

Site Status

Phenomix Investigational Site 110

Lynwood, California, United States

Site Status

Phenomix Investigational Site 118

Lynwood, California, United States

Site Status

Phenomix Investigational Site 119

Orange, California, United States

Site Status

Phenomix Investigational Site 109

Palm Springs, California, United States

Site Status

Phenomix Investigational Site 122

Whittier, California, United States

Site Status

Phenomix Investigational Site 112

Lauderdale Lakes, Florida, United States

Site Status

Phenomix Investigational Site 104

Ocala, Florida, United States

Site Status

Phenomix Investigational Site 116

Pembroke Pines, Florida, United States

Site Status

Phenomix Investigational Site 101

Augusta, Georgia, United States

Site Status

Phenomix Investigational Site 117

Honolulu, Hawaii, United States

Site Status

Phenomix Investigational Site 102

Baton Rouge, Louisiana, United States

Site Status

Phenomix Investigational Site 100

Rockville, Maryland, United States

Site Status

Phenomix Investigational Site 125

Rockville, Maryland, United States

Site Status

Phenomix Investigational Site 114

Springfield Gardens, New York, United States

Site Status

Phenomix Investigational Site 120

Winston-Salem, North Carolina, United States

Site Status

Phenomix Investigational Site 107

Columbia, South Carolina, United States

Site Status

Phenomix Investigational Site 111

Nashville, Tennessee, United States

Site Status

Phenomix Investigational Site 103

Fort Worth, Texas, United States

Site Status

Phenomix Investigational Site 106

Houston, Texas, United States

Site Status

Phenomix Investigational Site 108

San Antonio, Texas, United States

Site Status

Phenomix Investigational Site 113

Alexandria, Virginia, United States

Site Status

Phenomix Investigational Site 208

Kemerovo, , Russia

Site Status

Phenomix Investigational Site 203

Moscow, , Russia

Site Status

Phenomix Investigational Site 204

Moscow, , Russia

Site Status

Phenomix Investigational Site 209

Moscow, , Russia

Site Status

Phenomix Investigational Site 211

Moscow, , Russia

Site Status

Phenomix Investigational Site 205

Novosibirsk, , Russia

Site Status

Phenomix Investigational Site 207

Perm, , Russia

Site Status

Phenomix Investigational Site 206

Petrozavodsk, , Russia

Site Status

Phenomix Investigational Site 200

Saint Petersburg, , Russia

Site Status

Phenomix Investigational Site 201

Saint Petersburg, , Russia

Site Status

Phenomix Investigational Site 210

Saint Petersburg, , Russia

Site Status

Phenomix Investigational Site 212

Saint Petersburg, , Russia

Site Status

Phenomix Investigational Site 213

Saint Petersburg, , Russia

Site Status

Phenomix Investigational Site 304

Chernivtsi, , Ukraine

Site Status

Phenomix Investigational Site 300

Kyiv, , Ukraine

Site Status

Phenomix Investigational Site 301

Kyiv, , Ukraine

Site Status

Phenomix Investigational Site 306

Kyiv, , Ukraine

Site Status

Phenomix Investigational Site 302

Odesa, , Ukraine

Site Status

Phenomix Investigational Site 303

Vinnytsa, , Ukraine

Site Status

Phenomix Investigational Site 307

Zaporizhzhya, , Ukraine

Site Status

Countries

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United States Russia Ukraine

Other Identifiers

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PHX1149-PROT306

Identifier Type: -

Identifier Source: org_study_id

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