A Clinical Trial of CSL's 2009 H1N1 Influenza Vaccine (CSL425) in a Healthy Pediatric Population in the USA

NCT ID: NCT00958243

Last Updated: 2018-05-23

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

473 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-08-31

Study Completion Date

2010-04-30

Brief Summary

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The purpose of this study is to evaluate the immunogenicity and safety profile of CSL425 (CSL's 2009 H1N1 influenza vaccine) in a healthy pediatric population.

Detailed Description

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Conditions

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Influenza

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Placebo

Placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type BIOLOGICAL

Placebo

CSL425 (7.5 mcg)

7.5 mcg of hemagglutinin antigen per dose

Group Type EXPERIMENTAL

CSL's 2009 H1N1 Influenza Vaccine (CSL425)

Intervention Type BIOLOGICAL

0.25 mL intramuscular injection on Day 0 and Day 21

CSL425 (15 mcg)

15 mcg of hemagglutinin antigen per dose

Group Type EXPERIMENTAL

CSL's 2009 H1N1 Influenza Vaccine (CSL425)

Intervention Type BIOLOGICAL

0.5 mL intramuscular injection on Day 0 and Day 21

Interventions

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CSL's 2009 H1N1 Influenza Vaccine (CSL425)

0.5 mL intramuscular injection on Day 0 and Day 21

Intervention Type BIOLOGICAL

CSL's 2009 H1N1 Influenza Vaccine (CSL425)

0.25 mL intramuscular injection on Day 0 and Day 21

Intervention Type BIOLOGICAL

Placebo

Placebo

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Male or female aged \>= 6 months to \< 9 years at the time of the first study vaccination.
* For children \< 3 years of age at the time of first vaccination, born at or after 36 weeks gestation.

Exclusion Criteria

* Known hypersensitivity to a previous dose of influenza virus vaccine or allergy to eggs, chicken protein, neomycin, polymyxin, or any components of the Study Vaccine
Minimum Eligible Age

6 Months

Maximum Eligible Age

9 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Seqirus

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Clinical Director Vaccines

Role: STUDY_DIRECTOR

Seqirus

Locations

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Chandler, Arizona, United States

Site Status

Melbourne, Florida, United States

Site Status

Bardstown, Kentucky, United States

Site Status

Metairie, Louisiana, United States

Site Status

Omaha, Nebraska, United States

Site Status

Austintown, Ohio, United States

Site Status

Cincinnati, Ohio, United States

Site Status

Latrobe, Pennsylvania, United States

Site Status

Pittsburgh, Pennsylvania, United States

Site Status

Austin, Texas, United States

Site Status

Fort Worth, Texas, United States

Site Status

Houston, Texas, United States

Site Status

Murray, Utah, United States

Site Status

Countries

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United States

Other Identifiers

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CSLCT-CAL-09-62

Identifier Type: -

Identifier Source: org_study_id

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