Effects of Cardiac Rehabilitation for Individuals With Transient Ischemic Attack

NCT ID: NCT00929994

Last Updated: 2019-04-23

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 20 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2010-03-31
• Study Completion Date: 2014-11-30

Brief Summary

It is hypothesized that the addition of formal cardiac rehabilitation to standard care will result in long-term improvements in cardiovascular fitness and functional capacity in individuals who have suffered a transient ischemic attack (TIA) or minor stroke.

Furthermore, it is proposed that the addition of cardiac rehabilitation will influence depressive symptoms and cognition.

Detailed Description

A transient ischemic attack (TIA) is defined as an episode of neurological dysfunction caused by focal brain ischemia lasting less than 24 hours. Once an individual has suffered a TIA, preventative measures can be taken to target modifiable risk factors, one of which is physical inactivity. The current proposal focuses on the use of an established model of care (cardiac rehabilitation (CR)) and applies it to those who have suffered a TIA in order to maximize physical activity and minimize risk of future cardiovascular events. This will be a one-group pre/post design study with a 3 month non-intervention period. Participants will undergo measures at baseline and 3 months (non intervention period) then after 6 months of cardiac rehabilitation (cardiovascular fitness, 6 minute walk test, cognition, and depressive symptoms).

Conditions

Transient Ischemic Attack

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Exercise

Following a 3 month non intervention period, participants will participate in Cardiac Rehabilitation, carrying out an exercise program which will last 6 months and combine both resistance and aerobic training.

Cardiac Rehabilitation

Intervention Type: BEHAVIORAL

Individualized cardiac rehabilitation for 6 months, including health education sessions, as well as supervised exercise classes which include aerobic and resistance training.

Interventions

Cardiac Rehabilitation

Individualized cardiac rehabilitation for 6 months, including health education sessions, as well as supervised exercise classes which include aerobic and resistance training.

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Diagnosed with TIA
• Three months post-TIA
• Ability to understand the process and instructions for exercise training and provide informed consent

Exclusion Criteria

• Resting Blood Pressure greater than 160/100 despite medication
• Other cardiovascular morbidity which would limit exercise tolerance (heart failure, abnormal BP responses or STsegment depression > 2 mm, symptomatic aortic stenosis, complex arrhythmias)
• Current and extensive exercise participation
• Hypertrophic Cardiomyopathy
• Unstable Angina
• Orthostatic BP decrease of > 20 mm Hg with symptoms
• Other musculoskeletal impairments which would limit the participants ability to walk sufficient durations
• Pain or other co-morbidities (e.g., unclipped aneurysms, uncontrolled seizures etc.) which would preclude participation
• Cognitive or behavioural issues that would limit participation in exercise testing and training

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 100 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Heart and Stroke Foundation of Canada

OTHER

Sponsor Role: collaborator

Toronto Rehabilitation Institute

OTHER

Sponsor Role: lead

Responsible Party

Dina Brooks

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Dina Brooks, PhD

Role: PRINCIPAL_INVESTIGATOR

Toronto Rehabilitation Institute

William E McIllroy, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Waterloo

Paul Oh, MD

Role: PRINCIPAL_INVESTIGATOR

Toronto Rehabilitation Institute

Sandra Black, MD

Role: PRINCIPAL_INVESTIGATOR

Sunnybrook and Women's College Health Centre

Locations

Toronto Rehabilitation Institute - Rumsey Center

Toronto, Ontario, Canada

Countries

Canada

Other Identifiers

Brooks - 001

Identifier Type: -

Identifier Source: org_study_id