Study to Investigate the Immune Response to Two Doses of VAX102 Healthy Adults

NCT ID: NCT00921206

Last Updated: 2014-09-23

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1
• Total Enrollment: 21 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2009-06-30
• Study Completion Date: 2009-12-31

Brief Summary

The objective is to assess the humoral and cellular immune response of the VAX102 vaccine delivered IM and SC in a prime-boost regimen at dose levels 1 µg or 2 µg in healthy adults against the influenza A virus M2e antigen after each vaccination.

Detailed Description

The primary objective is to assess the humoral and cellular immune response of the VAX102 vaccine delivered IM and SC in a prime-boost regimen at dose levels 1 µg or 2 µg in healthy adults against the influenza A virus M2e antigen after each vaccination. The magnitude and quality of the M2e-specific B and T cells will be measured. B cell responses will be evaluated on pre-dose Days 0, 28 and post-dose Days 7, 35, 42 and 60. T cell responses will be measured on pre-dose Days 0, 28 and post-dose Days 14, 42 and 60. IgG M2e antibody will be measured on Days 0, 7, 14, 28, 35. 42 and 60. The secondary objective is to assess the safety, reactogenicity, and tolerability of the VAX102 vaccine delivered IM or SC at dose levels 1 µg or 2 µg, in a prime-boost dosing regimen, in healthy adults 18-49 years of age, inclusive.

Conditions

Influenza

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: NONE

Study Groups

VAX102 given i.m.

Universal influenza candidate vaccine

Group Type: ACTIVE_COMPARATOR

VAX102

Intervention Type: BIOLOGICAL

1 ug i.m. compared to 2 ug s.c.

VAX102 given s.c.

Universal influenza candidate vaccine

Group Type: ACTIVE_COMPARATOR

VAX102

Intervention Type: BIOLOGICAL

1 ug i.m. compared to 2 ug s.c.

Interventions

VAX102

1 ug i.m. compared to 2 ug s.c.

Intervention Type: BIOLOGICAL

Other Intervention Names

STF2.4xM2e

Eligibility Criteria

Inclusion Criteria

• Male or female aged 18 - 49 years inclusive
• Give written informed consent to participate.
• Healthy, as determined by medical history, physical examination, vital signs, and clinical safety laboratory examinations
• Females willing to practice birth control to avoid pregnancy during the study
• Comprehension of the study requirements, expressed availability for the required study period, and ability to attend scheduled visits.

Exclusion Criteria

• Presence of significant acute or chronic, uncontrolled medical or psychiatric illness (institution of new medical or surgical treatment, or a significant dose alteration for uncontrolled symptoms or drug toxicity within 3 months) as determined by medical history and/or physical exam.
• Cancer, or treatment for cancer, within 3 years. Persons with a history of cancer who are disease-free without treatment for 3 years or more are eligible
• Impaired immune responsiveness (of any cause), including diabetes mellitus.
• Documented influenza infection in the 6 months prior to study entry.
• Presently receiving or history of receiving any medications or treatments that affects the immune system such as allergy shots, immune globulin, interferon, immunomodulators, cytotoxic drugs or drugs known to be frequently associated with significant major organ toxicity, or systemic corticosteroids (oral or injectable) in the past 6 months. Inhaled and topical corticosteroids will be allowed.
• Receipt or planned administration of a nonstudy vaccine within 30 days before and during the study and through the Day 42 evaluation.
• History of anaphylactic type reaction to injected vaccines.
• History of drug or chemical abuse in the year before the study.
• Use of new prescription medications started within 7 days before study entry.
• Receipt of blood or blood products 8 weeks before study entry or planned administration during the study period.
• Donation of blood or blood products within 8 weeks before study entry or at any time during the study.
• Acute disease within 72 hours prior to vaccinations, defined as the presence of a moderate or severe illness (as determined by the investigator through medical history and physical examination; for example, those requiring an absence from work) with or without fever, or a fever >37.9ºC orally. Study vaccine can be administered to persons with a minor illness, such as diarrhea, or mild upper respiratory tract infection with or without low-grade febrile illness. Vaccination can be delayed until the subject has recovered.
• Any condition that, in the opinion of the investigator, might interfere with study objectives

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 49 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Colorado, Denver

OTHER

Sponsor Role: collaborator

VaxInnate Corporation

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Edward Janoff, MD

Role: PRINCIPAL_INVESTIGATOR

University of Colorado, Denver

Locations

Universite of Colorado, Denver

Denver, Colorado, United States

Countries

United States

Related Links

http://www.vaxinnate.com/

Sponsor website

Other Identifiers

VAX102-05

Identifier Type: -

Identifier Source: org_study_id