A Study to Learn About Flu and COVID-19 Vaccine Responses in Healthy People
NCT ID: NCT06683352
Last Updated: 2025-08-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE1/PHASE2
1353 participants
INTERVENTIONAL
2024-11-11
2025-07-15
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
QUADRUPLE
Study Groups
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Arm A
COVID-19 Vaccine (Dose 1) and Placebo
COVID-19 Vaccine
Pfizer-BioNTech COVID-19 Vaccine
Placebo
Saline
Arm B
COVID-19 Vaccine (Dose 2) and Placebo
COVID-19 Vaccine
Pfizer-BioNTech COVID-19 Vaccine
Placebo
Saline
Arm C
COVID-19 Vaccine (Dose 3) and Placebo
COVID-19 Vaccine
Pfizer-BioNTech COVID-19 Vaccine
Placebo
Saline
Arm D
Investigational Influenza Vaccine (Dose 1) and Placebo
Investigational Influenza Vaccine
Investigational Influenza Vaccine
Placebo
Saline
Arm E
Licensed Influenza Vaccine 1 and COVID-19 Vaccine (Dose 3)
COVID-19 Vaccine
Pfizer-BioNTech COVID-19 Vaccine
Licensed Influenza Vaccine 1
Licensed Influenza Vaccine 1
Arm EE
Licensed Influenza Vaccine 2 and COVID-19 Vaccine (Dose 3)
COVID-19 Vaccine
Pfizer-BioNTech COVID-19 Vaccine
Licensed Influenza Vaccine 2
Licensed Influenza Vaccine 2
Arm F
Investigational Influenza Vaccine (Dose 2) and Placebo
Investigational Influenza Vaccine
Investigational Influenza Vaccine
Placebo
Saline
Arm G
Influenza and COVID Combination Vaccine (Combination 1) and Placebo
Influenza and COVID Combination Vaccine
Combined investigational influenza and Pfizer-BioNTech COVID-19 Vaccine
Placebo
Saline
Arm H
Influenza and COVID Combination Vaccine (Combination 2) and Placebo
Influenza and COVID Combination Vaccine
Combined investigational influenza and Pfizer-BioNTech COVID-19 Vaccine
Placebo
Saline
Arm I
Influenza and COVID Combination Vaccine (Combination 3) and Placebo
Influenza and COVID Combination Vaccine
Combined investigational influenza and Pfizer-BioNTech COVID-19 Vaccine
Placebo
Saline
Arm J
Investigational Influenza Vaccine (Dose 3) and Placebo
Investigational Influenza Vaccine
Investigational Influenza Vaccine
Placebo
Saline
Arm K
Influenza and COVID Combination Vaccine (Combination 4) and Placebo
Influenza and COVID Combination Vaccine
Combined investigational influenza and Pfizer-BioNTech COVID-19 Vaccine
Placebo
Saline
Arm L
Influenza and COVID Combination Vaccine (Combination 5) and Placebo
Influenza and COVID Combination Vaccine
Combined investigational influenza and Pfizer-BioNTech COVID-19 Vaccine
Placebo
Saline
Arm M
Influenza and COVID Combination Vaccine (Combination 6) and Placebo
Influenza and COVID Combination Vaccine
Combined investigational influenza and Pfizer-BioNTech COVID-19 Vaccine
Placebo
Saline
Arm N
Influenza and COVID Combination Vaccine (Combination 7) and Placebo
Influenza and COVID Combination Vaccine
Combined investigational influenza and Pfizer-BioNTech COVID-19 Vaccine
Placebo
Saline
Interventions
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Investigational Influenza Vaccine
Investigational Influenza Vaccine
COVID-19 Vaccine
Pfizer-BioNTech COVID-19 Vaccine
Influenza and COVID Combination Vaccine
Combined investigational influenza and Pfizer-BioNTech COVID-19 Vaccine
Licensed Influenza Vaccine 1
Licensed Influenza Vaccine 1
Licensed Influenza Vaccine 2
Licensed Influenza Vaccine 2
Placebo
Saline
Eligibility Criteria
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Inclusion Criteria
* Healthy participants who are determined by medical history, physical examination (if clinically required), and clinical judgment of the investigator to be eligible for inclusion in the study.
Exclusion Criteria
* Treated with antiviral therapies for influenza (eg, Tamiflu) within 180 days prior to Day 1
Please refer to the study contact for further eligibility details.
18 Years
ALL
Yes
Sponsors
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Pfizer
INDUSTRY
BioNTech SE
INDUSTRY
Responsible Party
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Principal Investigators
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Pfizer CT.gov Call Center
Role: STUDY_DIRECTOR
Pfizer
Locations
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Orange County Research Center
Lake Forest, California, United States
Artemis Institute for Clinical Research
San Diego, California, United States
Diablo Clinical Research, Inc.
Walnut Creek, California, United States
Clinical Research Consulting
Milford, Connecticut, United States
Indago Research & Health Center, Inc
Hialeah, Florida, United States
Miami Dade Medical Research Institute, LLC
Miami, Florida, United States
Palm Springs Community Health Center
Miami Lakes, Florida, United States
Headlands Research Orlando
Orlando, Florida, United States
Clinical Research Atlanta
Stockbridge, Georgia, United States
East-West Medical Research Institute
Honolulu, Hawaii, United States
Clinical Research Professionals
Chesterfield, Missouri, United States
Bio-Kinetic Clinical Applications, LLC dba QPS-MO
Springfield, Missouri, United States
Bio-Kinetic Clinical Applications, LLC dba QPS-MO-Screening and Recruitment Center
Springfield, Missouri, United States
Velocity Clinical Research, Omaha
Omaha, Nebraska, United States
Las Vegas Clinical Trials
Las Vegas, Nevada, United States
ActivMed Practices & Research, LLC.
Portsmouth, New Hampshire, United States
DM Clinical Research- Cyfair
Houston, Texas, United States
SMS Clinical Research
Mesquite, Texas, United States
Dynamed Clinical Research, LP d/b/a DM Clinical Research
Tomball, Texas, United States
J. Lewis Research, Inc. / Foothill Family Clinic
Salt Lake City, Utah, United States
J. Lewis Research, Inc. / Foothill Family Clinic South
Salt Lake City, Utah, United States
Charlottesville Medical Research
Charlottesville, Virginia, United States
Countries
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Related Links
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To obtain contact information for a study center near you, click here.
Other Identifiers
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C5261023
Identifier Type: -
Identifier Source: org_study_id
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