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In-hospital Cardiac Arrest - Dynamics and State Transitions

NCT ID: NCT00920244

Last Updated: 2018-09-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

285 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-08-31

Study Completion Date

2015-04-30

Brief Summary

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The purpose of this study is to analyse transitions in cardiac rhythm and hemodynamic variables during resuscitation of patients with in-hospital cardiac arrest.

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Detailed Description

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In-hospital cardiac arrest carries a grave prognosis, with survival to discharge in the range of 15-20%. Key factors determining outcome include the presenting cardiac rhythm, aetiology, and early initiation of resuscitation. Some cardiac rhythms benefit from defibrillation (shockable rhythms). During resuscitation patients may switch between shockable and non-shockable rhythms, and may show signs of spontaneous circulation temporarily. Depending on rhythm and according to guidelines, patients receive direct current (DC) shocks (defibrillator) and/or i.v. adrenaline, atropine and amiodarone, which may affect state-transitions. We wish to make statistical analysis (time-series analysis, Markov modelling) of these state-transitions and variations in hemodynamic variables during resuscitation, related to CPR interventions and the cause of arrest. The cause of arrest will be determined based on chart records, interview with staff and autopsy if appropriate. One hypothesis is that differences in the patterns of state-transitions may reflect underlying aetiology, which may guide in future decision-making during resuscitation.

Conditions

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Heart Arrest Death, Sudden, Cardiac

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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Cardiopulmonary resuscitation (CPR)

CPR is performed according to international and national guidelines on all patients.

Intervention Type PROCEDURE

Epinephrine

According to guidelines epinephrine 1 mg i.v. is administered every 3 minutes during cardiopulmonary resuscitation.

Intervention Type DRUG

Atropine

According to CPR guidelines atropine 3 mg i.v. is administered if asystole og PEA with frequency \< 60 beat/min.

Intervention Type DRUG

Amiodarone

According to guidelines amiodarone 300 mg i.v. is administered if recurrent ventricular fibrillation/tachycardia (VF/VT) during CPR.

Intervention Type DRUG

External defibrillator

According to CPR guidelines patients with shockable rhythms may receive DC shocks. The defibrillator also stores physiological information regarding cardiac rhythm, pulse-oximetry, and end-tidal carbon dioxide (CO2) from endotracheal tube.

Intervention Type DEVICE

Other Intervention Names

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CPR Adrenaline Cordarone Defibrillator

Eligibility Criteria

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Inclusion Criteria

* Patients with in-hospital cardiac arrest who are resuscitated

Exclusion Criteria

* Younger than 18 years old
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Norwegian Air Ambulance Foundation

OTHER

Sponsor Role collaborator

Norwegian University of Science and Technology

OTHER

Sponsor Role collaborator

St. Olavs Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Eirik Skogvoll, MD, PhD

Role: STUDY_CHAIR

St. Olavs Hospital

Trond Nordseth, MD

Role: PRINCIPAL_INVESTIGATOR

St. Olavs Hospital

Locations

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St.Olavs Hospital, Department of Anesthesia

Trondheim, , Norway

Site Status

Countries

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Norway

References

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Skjeflo GW, Nordseth T, Loennechen JP, Bergum D, Skogvoll E. ECG changes during resuscitation of patients with initial pulseless electrical activity are associated with return of spontaneous circulation. Resuscitation. 2018 Jun;127:31-36. doi: 10.1016/j.resuscitation.2018.03.039. Epub 2018 Apr 3.

Reference Type RESULT
PMID: 29621571 (View on PubMed)

Nordseth T, Bergum D, Edelson DP, Olasveengen TM, Eftestol T, Wiseth R, Abella BS, Skogvoll E. Clinical state transitions during advanced life support (ALS) in in-hospital cardiac arrest. Resuscitation. 2013 Sep;84(9):1238-44. doi: 10.1016/j.resuscitation.2013.04.010. Epub 2013 Apr 19.

Reference Type DERIVED
PMID: 23603153 (View on PubMed)

Other Identifiers

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08/11457

Identifier Type: OTHER

Identifier Source: secondary_id

20708/2/IB

Identifier Type: OTHER

Identifier Source: secondary_id

4.2008.2402 (REK)

Identifier Type: -

Identifier Source: org_study_id

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