The Study of NPC-06 - Investigation of Safety, Efficacy and Pharmacokinetics of Fosphenytoin

NCT ID: NCT00908453

Last Updated: 2010-05-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-05-31

Study Completion Date

2010-02-28

Brief Summary

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The study is to evaluate safety, efficacy and pharmacokinetics of intravenously administered fosphenytoin in patients with neurosurgery, head trauma, epilepsy or status epilepticus who are requiring a loading dose of phenytoin.

Detailed Description

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Conditions

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Epilepsy

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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15mg/kg of loading dose

Group Type EXPERIMENTAL

fosphenytoin

Intervention Type DRUG

15mg/kg, 18mg/kg or 22.5mg/kg of loading doses of fosphenytoin

18mg/kg of loading dose

Group Type EXPERIMENTAL

fosphenytoin

Intervention Type DRUG

15mg/kg, 18mg/kg or 22.5mg/kg of loading doses of fosphenytoin

22.5mg/kg of loading dose

Group Type EXPERIMENTAL

fosphenytoin

Intervention Type DRUG

15mg/kg, 18mg/kg or 22.5mg/kg of loading doses of fosphenytoin

Interventions

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fosphenytoin

15mg/kg, 18mg/kg or 22.5mg/kg of loading doses of fosphenytoin

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* male or female, hospitalized patients 2 years of age or older
* Adult patients or guardian for pediatric patients to provide written informed consent

Exclusion Criteria

* patient with a history of hypersensitivity to hydantoins
* patient with hypotension, sinus bradycardia, sino-atrial block, second or third degree A-V block, or Adams-Stokes syndrome
* pregnant or nursing female patients
Minimum Eligible Age

2 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Nobelpharma

INDUSTRY

Sponsor Role lead

Responsible Party

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CNS group

Principal Investigators

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Eiji Nakagawa, M.D.

Role: STUDY_DIRECTOR

National Center of Neurology and Psychiatry

Locations

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National Center of Neurology and Psychiatry

Kodaira, Tokyo, Japan

Site Status

Countries

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Japan

Other Identifiers

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NPC-06-2

Identifier Type: -

Identifier Source: org_study_id

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