The Effects of Preconditioning on Intramuscular High-Energy Phosphate Levels During Ischemia
NCT ID: NCT00883467
Last Updated: 2009-04-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
16 participants
INTERVENTIONAL
2008-05-31
Brief Summary
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A cross-over design of 4 to 8 study periods is used, 4 different study days with 2 different MR measurement methods (BOLD imaging and high energy phosphates) are planned.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
NONE
Study Groups
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1
baseline MR signal prior to, during and 30 minutes after an ischemic period of 20 minutes
no preconditioning
no preconditioning
2
baseline MR signal prior to, during and 30 minutes after an ischemic period of 20 minutes with additional 5 minutes of cuff stenosis directly after cuff release
no preconditioning
no preconditioning
3
short time preconditioning, other details according arm 2
preconditioning
3 times of five minutes ischemia, produced by cuff inflation to a suprasystolic pressure positioned on the thigh
4
long time preconditioning, other details according arm 2
preconditioning
3 times of five minutes ischemia, produced by cuff inflation to a suprasystolic pressure positioned on the thigh
Interventions
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preconditioning
3 times of five minutes ischemia, produced by cuff inflation to a suprasystolic pressure positioned on the thigh
no preconditioning
no preconditioning
Eligibility Criteria
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Inclusion Criteria
* Nonsmoker for more than 3 months
* Body mass index between 18 and 25 kg/m2
* Normal findings in medical history and physical examination unless the investigator considers an abnormality to be clinically irrelevant
Exclusion Criteria
* Evidence of hypertension, pathologic hyperglycemia, hyperlipidemia
* Treatment in the previous 3 weeks with any drug including over-the-counter drugs
* Symptoms of a clinically relevant illness in the 2 weeks before the first study day
* Blood donation during the previous 3 weeks
* Any metallic, electric, electronic or magnetic device or object not removable
* Claustrophobia
18 Years
45 Years
MALE
Yes
Sponsors
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Medical University of Vienna
OTHER
Responsible Party
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Medical University of Vienna, Department of Clinical Pharmacology
Principal Investigators
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Michael Wolzt, MD
Role: PRINCIPAL_INVESTIGATOR
MUV, Department of Clinical Pharmacology
Locations
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Medical University of Vienna, Department of Clinical Pharmacology
Vienna, , Austria
Countries
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References
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Andreas M, Schmid AI, Keilani M, Doberer D, Bartko J, Crevenna R, Moser E, Wolzt M. Effect of ischemic preconditioning in skeletal muscle measured by functional magnetic resonance imaging and spectroscopy: a randomized crossover trial. J Cardiovasc Magn Reson. 2011 Jun 30;13(1):32. doi: 10.1186/1532-429X-13-32.
Other Identifiers
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IPC in MRI 040908
Identifier Type: -
Identifier Source: org_study_id
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