Long or Very Long-Limb Gastric Bypass in Superobese

NCT ID: NCT00868543

Last Updated: 2009-03-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE3

Total Enrollment

150 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-07-31

Study Completion Date

2015-12-31

Brief Summary

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The goal of this study is to compare the clinical efficacy (weight loss and metabolic changes) of long (150 cm) versus very long (250cm) Roux alimentary limb gastric bypass in superobese (BMI\>50) patients.

Detailed Description

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The study is a multicentre trial in which superobese (BMI\>50) patients will be randomly assigned (in a 1:1 ratio) for laparoscopic gastric Roux-en-Y gastric bypass with: a) long (150 cm) or b) very long (250cm) alimentary Roux limb. Patients will be included from three hospitals: Kaunas University of Medicine Hospital (Lithuania), Klaipeda District Hospital (Lithuania), Vaasa Central Hospital (Finland) ) where preoperative investigation, the same technique surgical procedures and follow up will be performed acording approved protocol.

Approximate duration of subject participation

Subjects in the study will participate for approximately 5 years:

* Preoperative investigation and surgery 3- 5 days in the hospital;
* First follow up visit: 6 months after surgery;
* Next follow up visits: 12, 24, 36, 48 months after surgery;
* Last follow up visit: 5 years after surgery.
* The interim results after 12, 24 and 36 months will be calculated and presented before end of the study.

Conditions

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Obesity

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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Long limb

Hospitalized male or female subjects 18-65 years of age,obese with body mass index (BMI= kg/m²)\>50.Patients without mental or nervous disorders interfering with adequate evaluation of one's health condition, who read the informed consent form and gave a written consent to participate in the study. Gastric bypass was performed with long (150 cm) alimentary Roux limb

Group Type ACTIVE_COMPARATOR

laparoscopic gastric Roux-en-Y gastric bypass

Intervention Type PROCEDURE

The fundus is separated by linear cutter. The intestine is opened approximately 75 cm from the ligament of Treitz and approached to the stomach. The gastrojejunostomy is performed in antecolic position The jejunum has to be in an antimesenteric position. After removing the endocutter, the anastomotic incision is closed with a continuous suture. The distance between the gastrojejunostomy and jejunojejunostomy was measured on the antimesenteric border with the bowel on a stretch. The jejunojejunostomy is performed in 150cm distance from gastrojejunostomy. The anastomosis is made by a posterior staple line and an anterior suture line. Preparation of a small window for the endocutter branches into the jejunal mesenterium 2-3 cm proximal to the gastrojejunostomy and above the entero-intestinal anastomosis.

Very long limb

Hospitalized male or female subjects 18-65 years of age,obese with body mass index (BMI= kg/m²)\>50.Patients without mental or nervous disorders interfering with adequate evaluation of one's health condition, who read the informed consent form and gave a written consent to participate in the study. Gastric bypass was performed with very long (250 cm) alimentary Roux limb

Group Type ACTIVE_COMPARATOR

laparoscopic gastric Roux-en-Y gastric bypass

Intervention Type PROCEDURE

The fundus is separated by linear cutter. The intestine is opened approximately 75 cm from the ligament of Treitz and approached to the stomach. The gastrojejunostomy is performed in antecolic position The jejunum has to be in an antimesenteric position. After removing the endocutter, the anastomotic incision is closed with a continuous suture. The distance between the gastrojejunostomy and jejunojejunostomy was measured on the antimesenteric border with the bowel on a stretch. The jejunojejunostomy is performed in 250cm distance from gastrojejunostomy. The anastomosis is made by a posterior staple line and an anterior suture line. Preparation of a small window for the endocutter branches into the jejunal mesenterium 2-3 cm proximal to the gastrojejunostomy and above the entero-intestinal anastomosis.

Interventions

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laparoscopic gastric Roux-en-Y gastric bypass

The fundus is separated by linear cutter. The intestine is opened approximately 75 cm from the ligament of Treitz and approached to the stomach. The gastrojejunostomy is performed in antecolic position The jejunum has to be in an antimesenteric position. After removing the endocutter, the anastomotic incision is closed with a continuous suture. The distance between the gastrojejunostomy and jejunojejunostomy was measured on the antimesenteric border with the bowel on a stretch. The jejunojejunostomy is performed in 150cm distance from gastrojejunostomy. The anastomosis is made by a posterior staple line and an anterior suture line. Preparation of a small window for the endocutter branches into the jejunal mesenterium 2-3 cm proximal to the gastrojejunostomy and above the entero-intestinal anastomosis.

Intervention Type PROCEDURE

laparoscopic gastric Roux-en-Y gastric bypass

The fundus is separated by linear cutter. The intestine is opened approximately 75 cm from the ligament of Treitz and approached to the stomach. The gastrojejunostomy is performed in antecolic position The jejunum has to be in an antimesenteric position. After removing the endocutter, the anastomotic incision is closed with a continuous suture. The distance between the gastrojejunostomy and jejunojejunostomy was measured on the antimesenteric border with the bowel on a stretch. The jejunojejunostomy is performed in 250cm distance from gastrojejunostomy. The anastomosis is made by a posterior staple line and an anterior suture line. Preparation of a small window for the endocutter branches into the jejunal mesenterium 2-3 cm proximal to the gastrojejunostomy and above the entero-intestinal anastomosis.

Intervention Type PROCEDURE

Other Intervention Names

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laparoscopic gastric bypass laparoscopic gastric bypass

Eligibility Criteria

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Inclusion Criteria

* Hospitalized male or female subjects 18-65 years of age.
* Obese subjects with body mass index (BMI= kg/m²)\>50
* Patients without mental or nervous disorders interfering with adequate evaluation of one's health condition.
* Patients who read the informed consent form and gave a written consent to participate in the study.

Exclusion Criteria

* Previous open abdominal surgery, except appendectomy, cholecystectomy and gynaecological procedures.
* Presence of any significance cardiac, hepatic, renal, blood, alimentary tract disease which may lead to system or organ failure in intraoperative or postoperative period.
* Pregnant women.
* Subjects taking immunosuppressive therapy.
* Any concomitant condition that, in the opinion of the investigator, would preclude an operation and postoperative follow up acording to a protocol
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Kaunas University of Medicine

OTHER

Sponsor Role lead

Responsible Party

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Kaunas University of Medicine

Principal Investigators

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Almantas Maleckas

Role: PRINCIPAL_INVESTIGATOR

Kaunas University of Medicine

Locations

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KMUK, surgery department

Kaunas, , Lithuania

Site Status RECRUITING

Countries

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Lithuania

Central Contacts

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Nerijus Kaselis

Role: CONTACT

+37069943431

Almantas Maleckas

Role: CONTACT

+37068531143

Facility Contacts

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Nerijus Kaselis

Role: primary

+37069943431

Other Identifiers

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BE-2-37

Identifier Type: -

Identifier Source: org_study_id

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