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Neurohumoral Control of Intestinal Electrical and Mechanical Activity

NCT ID: NCT00852553

Last Updated: 2017-05-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

45 participants

Study Classification

OBSERVATIONAL

Study Start Date

2003-02-28

Study Completion Date

2012-02-29

Brief Summary

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A collaborative research project with Dr. Kathleen Keef (Department of Physiology, University of Nevada School of Medicine, Reno, Nevada) studying the role of putative neurotransmitters in human intestine.

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Detailed Description

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Segments of intestine from patients undergoing elective gastric bypass for morbid obesity or resections for non-obstructive neoplasms at the UC Davis Medical Center will be used. Samples will be taken from tissue normally removed and sent to Pathology or discarded. Full thickness segments of intestine (10 mm x 1 mm) will be prepared for recording either intracellular electrical activity or mechanical contraction. The effects of putative non-adrenergic, non-cholinergic neurotransmitters (e.g., nitric oxide) will be studied. The source of the tissue will not be identified either directly or indirectly through identifiers associated with the measured responses.

Conditions

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Morbid Obesity

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* All patients having elective bowel resection

Exclusion Criteria

* Entire resected segment required for pathology
* Ischemic/necrotic disease
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of California, Davis

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Neal W. Fleming, M.D., Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Professor

Locations

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University of California, Davis Medical Center

Sacramento, California, United States

Site Status

University of Nevada School of Medicine

Reno, Nevada, United States

Site Status

Countries

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United States

Other Identifiers

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200311379-8

Identifier Type: -

Identifier Source: secondary_id

200311379

Identifier Type: -

Identifier Source: org_study_id

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