Study on Whether Tart Cherry Juice Can Reduce Oxidative Stress and Inflammation

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-10-31

Study Completion Date

2008-04-30

Brief Summary

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Oxidative stress has been linked to many diseases associated with aging, including coronary heart disease and Alzheimer's disease. Antioxidants and special proteins in the body work together to help prevent damage by free radicals. Some studies have indicated that as people age, they are less able to fight off oxidative stress and have increased levels of inflammation.

Tart cherries are known to be rich in antioxidants and plant-nutrients. The product we are using in this study is an all-natural tart cherry juice, mixed with apple juice concentrate and containing no additives and no preservatives.

We hope to learn whether antioxidant supplementation, such as tart cherry juice, can measurably decrease oxidative damage and inflammation associated with aging.

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Detailed Description

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Objectives

The primary objective of this pilot study is to investigate whether tart cherry juice consumption can reduce oxidative stress in older adults as measured by attenuation of F2-isoprostane responses to a forearm ischemia-reperfusion, and a decrease in urinary excretion products of oxidative damage. The secondary objective is to examine whether age-sensitive markers of inflammation are reduced in response to the cherry juice consumption.

Conditions

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Oxidative Stress Antioxidant Capacity Inflammation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Investigators

Interventions

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Tart Cherry Juice

8 fl.oz. twice per day

Intervention Type DIETARY_SUPPLEMENT

Other Intervention Names

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CherryPharm

Eligibility Criteria

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Inclusion Criteria

* men and women, ages 55-80y, in good health, with \>8 years of education
* non-smoker
* able to give informed consent

Exclusion Criteria

* use of anti-oxidant supplements, in excess of a standard multi-vitamins
* current hormone replacement therapy
* any history of significant chronic disease
* uncontrolled hypertension
* body mass index (BMI) \> 30 kg/m2
* high physical activity level, as determined by questions on the screening questionnaire
* use of anti-inflammatory medication

Minimum Eligible Age

55 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes