Comparison of Ascorbic Acid and Grape Seed Extract in Oxidative Stress Induced by on Pump Heart Surgery
NCT ID: NCT00839085
Last Updated: 2009-02-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
72 participants
INTERVENTIONAL
2008-11-30
2009-03-31
Brief Summary
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Detailed Description
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There are three groups in the study. 75 candidate of coronary artery by pass grafting surgery were assigned random allocation on the groups (25 in each group).
1. Control
2. GSE (100 mg/6h - PO, 24h before surgery)
3. Vit C (25 mg/kg in pump circulation during surgery)
Conditions
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Study Design
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RANDOMIZED
PARALLEL
SUPPORTIVE_CARE
DOUBLE
Study Groups
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1
normal procedure of CABG
No interventions assigned to this group
2: GSE
100 mg GSE every 6h /Po, starting one day before surgery (4 doses in 24h)
GSE
grape seed extract (100 mg/6h), PO
3: Vit C
25 mg/kg through pump
Vit C (Ascorbic Acid)
Vit C 25 mg/ kg
Interventions
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GSE
grape seed extract (100 mg/6h), PO
Vit C (Ascorbic Acid)
Vit C 25 mg/ kg
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* 3VD
Exclusion Criteria
* Those who need another heart surgery beside CABG
* Urgent patients
* Diabetics
* Ischemic time more than 120 min
ALL
No
Sponsors
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Tabriz University
OTHER
Responsible Party
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Cardiovascular Research Center
Principal Investigators
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Hossein Babaei, Pharm D, PhD
Role: PRINCIPAL_INVESTIGATOR
Drug Applied Research Center, Tabriz Univ Med Sci
Naser Safaei, MD, Surgeon
Role: STUDY_CHAIR
Tabriz Univ Med Sci
Masood Pezaeshkian, MD
Role: PRINCIPAL_INVESTIGATOR
Tabriz Univ Med Sci
Alireza Yaghobi, MD
Role: PRINCIPAL_INVESTIGATOR
Tabriz Univ Med Sci
Ahmad Reza Jodati, MD
Role: PRINCIPAL_INVESTIGATOR
Tabriz Univ Med Sci
Hossein Babaei, Pharm D, PhD
Role: STUDY_DIRECTOR
Tabriz Univ Med Sci
Rasoul Azarfarin, MD
Role: PRINCIPAL_INVESTIGATOR
Tabriz Univ Med Sci
Mohammad Ali Sheikhalizadeh, CCP
Role: STUDY_DIRECTOR
Tabriz Univ Med Sci
Locations
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Cardiovascular Research Center
Tabriz, East Azerbaijan Province, Iran
Countries
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Other Identifiers
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8710
Identifier Type: -
Identifier Source: org_study_id
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