Study of Impacts of Food Supplementation on Malnourished HIV-Infected Adults in Kenya

NCT ID: NCT00838292

Last Updated: 2009-03-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

1049 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-08-31

Study Completion Date

2008-06-30

Brief Summary

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The purpose of the study is to test whether food supplementation of malnourished HIV-infected adults (both pre-ART and ART) in resource constrained settings improves their nutritional status, clinical status, effectiveness of treatment, quality of life, functioning, and survival.

Detailed Description

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Malnutrition remains a significant problem among HIV-infected populations, even among those with access to ART. In patients with HIV infection, poor nutritional status is associated with significant reduction in survival rates, accelerated disease progression, diminished response to therapies including ART, increased susceptibility to opportunistic infections, and reduced work capacity and quality of life. However, there is not evidence whether delay or reversal of weight loss improves life expectancy, nor is there evidence about the specific benefits food supplementation has on people with HIV infection. As antiretroviral therapy (ART) services continue to scale up in sub-Saharan Africa, there is a critical need for information about the impacts of appropriate food supplementation on the effectiveness of ART, on the health status of clients, and on the progression of the disease.

Malnourished adult ART and pre-ART clients at six clinical sites in Kenya are randomly allocated either to a group that receives nutrition counseling only or a group that receives nutrition counseling and supplementary feeding for six months. All patients continue to receive medical treatment (ART and other medicine) according to their condition. Baseline measures of socioeconomic and demographic status are collected. Measures of both nutritional and non-nutritional clinical outcomes are collected at baseline, 3, 6, 9, and 12 months. Clients beginning ART are treated as one arm and randomized between food and non-food, and clients not yet eligible for ART (pre-ART) are treated as a second arm and randomized between food and non-food. Within each arm, outcomes of subjects receiving supplemental food will be compared with outcomes of those who are not.

Conditions

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HIV Malnutrition HIV Infections

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

DOUBLE

Investigators Outcome Assessors

Study Groups

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ART: food

ART + food supplementation + nutrition counseling

Group Type ACTIVE_COMPARATOR

fortified blended flour - Insta Foundation Plus (with whey protein concentrate)

Intervention Type DIETARY_SUPPLEMENT

300 grams/day for 6 months

nutrition counseling

Intervention Type OTHER

ART: no food

ART + nutrition counseling

Group Type ACTIVE_COMPARATOR

nutrition counseling

Intervention Type OTHER

pre-ART: food

no ART (cotrimoxazole provided) + food supplementation + nutrition counseling

Group Type ACTIVE_COMPARATOR

fortified blended flour - Insta Foundation Plus (with whey protein concentrate)

Intervention Type DIETARY_SUPPLEMENT

300 grams/day for 6 months

nutrition counseling

Intervention Type OTHER

pre-ART: no food

no ART (cotrimoxazole provided) + nutrition counseling

Group Type ACTIVE_COMPARATOR

nutrition counseling

Intervention Type OTHER

Interventions

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fortified blended flour - Insta Foundation Plus (with whey protein concentrate)

300 grams/day for 6 months

Intervention Type DIETARY_SUPPLEMENT

nutrition counseling

Intervention Type OTHER

Other Intervention Names

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Insta Products Ltd. Foundation Plus product with whey protein concentrate.

Eligibility Criteria

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Inclusion Criteria

* HIV-infected
* BMI \< 18.5
* Resident of area for past 6 months

Exclusion Criteria

* Pregnant or lactating (child \< 6 months)
* BMI \> 18.5, BMI \< 14
* Already receiving other food supplements
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Kenya Medical Research Institute

OTHER

Sponsor Role collaborator

Academy for Educational Development

INDUSTRY

Sponsor Role lead

Responsible Party

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Academy for Educational Development, FANTA Project

Principal Investigators

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James Muttunga, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Kenya Medical Research Institute

Robert Mwadime, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Academy for Educational Development, FANTA Project

Locations

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Maragwa District Hospital

Maragwa, , Kenya

Site Status

Mathere North Hospital

Nairobi, , Kenya

Site Status

Mbagathi District Hospital

Nairobi, , Kenya

Site Status

Riruta City Council Hospital

Nairobi, , Kenya

Site Status

Naivasha District Hospital

Naivasha, , Kenya

Site Status

Nyeri Provincial Hospital

Nyeri, , Kenya

Site Status

Countries

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Kenya

Other Identifiers

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AED 1

Identifier Type: -

Identifier Source: org_study_id

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