Early Continuous Renal Replacement Therapies (CRRT) in Patients With Severe Sepsis or Septic Shock With Acute Kidney Injury

NCT ID: NCT00837057

Last Updated: 2009-02-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE4

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-02-28

Brief Summary

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Severe sepsis or septic shock with acute kidney injury shows high mortality in intensive care unit. A few studies have shown CRRT relating the clinical improvement seems to be related to the early initiation of therapy. But there is no consensus for proper time of CRRT may improve the prognosis.

The study is a prospective randomized one center trial comparing two treatments in patients suffering from septic shock complicated with acute renal failure admitted to ICU, treated either early by CRRT (35 ml/kg/h) or by conventional RRT.

Detailed Description

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Conditions

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Severe Sepsis Septic Shock Acute Kidney Injury

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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early crrt, late crrt

Group Type OTHER

crrt

Intervention Type PROCEDURE

early CRRT (35 ml/kg/h)\& acute kidney injury or failure or nearly anuria more than 2hr or late conventional dialysis indication

Interventions

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crrt

early CRRT (35 ml/kg/h)\& acute kidney injury or failure or nearly anuria more than 2hr or late conventional dialysis indication

Intervention Type PROCEDURE

Other Intervention Names

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renal replacement therapy, timing

Eligibility Criteria

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Inclusion Criteria

* Septic shock (Bone criteria) for less than 14D
* RIFLE criteria : Injury or Failure or nearly anuria more than 2hr
* Age over 18 years
* Written informed consent by next of kin.

Exclusion Criteria

* Cirrhosis child class C
* CRF or ESRD
* Too high APACHE II \& SOFA score at admission
* Age over 80 years
* Life expectancy less than 3 months (metastatic cancer - hepatoma, lung ca.)
Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Asan Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Asan Medical Center

Locations

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Asan Medical Center

Seoul, , South Korea

Site Status

Countries

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South Korea

Central Contacts

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sangbum hong, md

Role: CONTACT

82-2-3010-3893

Facility Contacts

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sangbum hong, md

Role: primary

82-2-3010-3893

References

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Fayad AI, Buamscha DG, Ciapponi A. Timing of kidney replacement therapy initiation for acute kidney injury. Cochrane Database Syst Rev. 2022 Nov 23;11(11):CD010612. doi: 10.1002/14651858.CD010612.pub3.

Reference Type DERIVED
PMID: 36416787 (View on PubMed)

Other Identifiers

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a085068

Identifier Type: -

Identifier Source: org_study_id

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