Airway Clearance Using High Frequency Chest Wall Oscillation

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-01-31

Study Completion Date

2007-09-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

High frequency chest wall oscillation (HFCWO) has been shown to increase tracheal mucous clearance compared with control. These observations led to the development of 'The Vest' which is a non-stretchable jacket connected to an air-pulse generator and worn by the patient over the chest wall. The generator rapidly inflates and deflates 'The Vest' which gently compresses and releases the chest wall between 5 and 20 times per second. This generates mini-coughs which are said to dislodge mucus from the bronchial walls and to facilitate its movement up the airways. In addition 'The Vest' has been shown to reduce the viscosity of mucus and this should further enhance mucous clearance. The technique has, for many years, been widely used in the United States of America as an alternative to the European airway clearance regimens of the active cycle of breathing techniques, autogenic drainage, positive expiratory pressure and oscillating positive expiratory pressure, but 'The Vest' has only recently been registered for use in Europe. It is important that the airway clearance regimen of 'The Vest' be compared with the alternative airway clearance regimens widely used in Europe.

Hypothesis: In people with cystic fibrosis 'The Vest' will lead to the expectoration of an increased weight of sputum during treatment sessions compared with alternative airway clearance regimens.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

HFCWO in Prolonged Mechanical Ventilation Patients

NCT02077738

Chronic Ventilator Dependency

COMPLETED NA

HFCWO on Pneumonic Respiratory Failure

NCT02758106

Acute Respiratory Failure Pneumonia

COMPLETED NA

Non Invasive Ventilation for Acute Exacerbations in Adult CF

NCT02234401

Cystic Fibrosis Respiratory Failure

UNKNOWN NA

VICOR Study-High Frequency Chest Wall Oscillations (HFCWO) in Patients With Acute Respiratory Failure and Hypersecretion

NCT05751707

Acute Respiratory Failure Acute-on-chronic Respiratory Failure Airway Clearance Impairment

UNKNOWN NA

Comparison of a Hyperinflation Mode and Air Stacking on Neuromuscular Patients Under Volumetric Ventilation

NCT02847299

Neuromuscular Disease

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Cystic Fibrosis

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Usual airway clearance technique

Airway clearance using the active cycle of breathing techniques, autogenic drainage, positive expiratory pressure or oscillating positive expiratory pressure

Group Type ACTIVE_COMPARATOR

High frequency chest wall oscillation

Intervention Type DEVICE

Airway clearance using high frequency chest wall oscillation ('The Vest')

HFCWO

High frequency chest wall oscillation

Group Type OTHER

High frequency chest wall oscillation

Intervention Type DEVICE

Airway clearance using high frequency chest wall oscillation ('The Vest')

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

High frequency chest wall oscillation

Airway clearance using high frequency chest wall oscillation ('The Vest')

Intervention Type DEVICE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* diagnosis of cystic fibrosis
* 16 years of age or over
* forced expiratory volume in one second greater than or equal to 25 percent of predicted
* hospitalised patients in a stable clinical state