Full Disclosure Observational Cardiac Rhythm Documentation Follow-up After Surgical Atrial Fibrillation Therapy

NCT ID: NCT00806689

Last Updated: 2010-07-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2007-07-31

Study Completion Date

2011-07-31

Brief Summary

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24 hour Holter monitoring (24HM) is commonly used to assess cardiac rhythm after surgical therapy of atrial fibrillation. This "snapshot" rhythm documentation leaves a large diagnostic window of non recorded atrial arrhythmias and as such a large amount of uncertainty in follow-up result assessment. To improve accuracy of rhythm surveillance thus gaining a more "real-life" scenario of post surgical ablation therapy cardiac rhythm a new insertable cardiac rhythm monitor device (Reveal® XT 9525, Medtronic Inc., Minneapolis, MN, USA) with full observational continuous heart rhythm documentation is implanted.

In order to verify different follow-up strategies after surgical atrial fibrillation therapy, a comparison of different follow-up scenarios (symptoms, different cardiac documentation devices i.e. ECG and 24 hour Holter monitor, at different follow-up time points) is performed intraindividually. Thus the reliability of these devices and follow-up strategies to define success after ablation therapy is evaluated.

Detailed Description

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Conditions

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Atrial Fibrillation

Study Design

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Observational Model Type

COHORT

Study Groups

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Cardiac surgery patients

Patients in atrial fibrillation being scheduled for cardiac surgery and concomitant ablation procedure

Cardiac rhythm monitor implantation

Intervention Type PROCEDURE

post surgical procedure implantation of insertable event recorder for long time heart rhythm surveillance afte ablation therapy

Reveal® XT 9525

Intervention Type DEVICE

During cardiac surgery after stand alone or concomitant ablation procedure, an insertable loop recorder will be implanted subcutaneously in left pectoral region. After surgery, patients will be monitored regularly in a quarterly basis by performing telemetry of the device in the outpatient clinic. Furthermore, home telemetry will be performed once a month for optimal heart rhythm observation.

Interventions

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Cardiac rhythm monitor implantation

post surgical procedure implantation of insertable event recorder for long time heart rhythm surveillance afte ablation therapy

Intervention Type PROCEDURE

Reveal® XT 9525

During cardiac surgery after stand alone or concomitant ablation procedure, an insertable loop recorder will be implanted subcutaneously in left pectoral region. After surgery, patients will be monitored regularly in a quarterly basis by performing telemetry of the device in the outpatient clinic. Furthermore, home telemetry will be performed once a month for optimal heart rhythm observation.

Intervention Type DEVICE

Other Intervention Names

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Reveal® XT 9525, Medtronic Inc., Minneapolis, MN, USA

Eligibility Criteria

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Inclusion Criteria

* patients in atrial fibrillation (AF duration \>4 months)being scheduled for cardiac surgery
* patients with lone atrial fibrillation being scheduled for surgical AF treatment

Exclusion Criteria

* failure to provide informed consent
* current participation in another clinical trial
* organic cause of atrial fibrillation (hyperthyroidism etc.)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Luebeck

OTHER

Sponsor Role lead

Responsible Party

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Clinic for Cardiac and Thoracic Vascular Surgery, University of Luebeck

Principal Investigators

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Hans-H. Sievers, M.D.

Role: STUDY_DIRECTOR

Clinic for Cardiac and Thoracic Vascular Surgery, University of Luebeck, germany

Thorsten Hanke, M.D.

Role: PRINCIPAL_INVESTIGATOR

Clinic for Cardiac and Thoracic Vascular Surgery, University of Luebeck, germany

Ulrich Stierle, M.D.

Role: STUDY_CHAIR

Clinic for Cardiac and Thoracic Vascular Surgery, University of Luebeck, Germany

Locations

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Clinic for Cardiac and Thoracic Vascular Surgery, University of Lübeck, Germany

Lübeck, Schleswig-Holstein, Germany

Site Status RECRUITING

Countries

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Germany

Central Contacts

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Thorsten Hanke, MD

Role: CONTACT

0049-451-500 ext. 2108

Facility Contacts

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Hans-H. Sievers, M.D.

Role: primary

0049451500 ext. 2108

Thorsten Hanke, M.D.

Role: backup

0049451500 ext. 2108

References

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Hanke T, Charitos EI, Stierle U, Karluss A, Kraatz E, Graf B, Hagemann A, Misfeld M, Sievers HH. Twenty-four-hour holter monitor follow-up does not provide accurate heart rhythm status after surgical atrial fibrillation ablation therapy: up to 12 months experience with a novel permanently implantable heart rhythm monitor device. Circulation. 2009 Sep 15;120(11 Suppl):S177-84. doi: 10.1161/CIRCULATIONAHA.108.838474.

Reference Type RESULT
PMID: 19752365 (View on PubMed)

Charitos EI, Ziegler PD, Stierle U, Robinson DR, Graf B, Sievers HH, Hanke T. Atrial fibrillation burden estimates derived from intermittent rhythm monitoring are unreliable estimates of the true atrial fibrillation burden. Pacing Clin Electrophysiol. 2014 Sep;37(9):1210-8. doi: 10.1111/pace.12389. Epub 2014 Mar 25.

Reference Type DERIVED
PMID: 24665972 (View on PubMed)

Charitos EI, Ziegler PD, Stierle U, Robinson DR, Graf B, Sievers HH, Hanke T. How often should we monitor for reliable detection of atrial fibrillation recurrence? Efficiency considerations and implications for study design. PLoS One. 2014 Feb 12;9(2):e89022. doi: 10.1371/journal.pone.0089022. eCollection 2014.

Reference Type DERIVED
PMID: 24563690 (View on PubMed)

Charitos EI, Stierle U, Ziegler PD, Baldewig M, Robinson DR, Sievers HH, Hanke T. A comprehensive evaluation of rhythm monitoring strategies for the detection of atrial fibrillation recurrence: insights from 647 continuously monitored patients and implications for monitoring after therapeutic interventions. Circulation. 2012 Aug 14;126(7):806-14. doi: 10.1161/CIRCULATIONAHA.112.098079. Epub 2012 Jul 23.

Reference Type DERIVED
PMID: 22824434 (View on PubMed)

Other Identifiers

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08-046

Identifier Type: -

Identifier Source: org_study_id

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