A Study to Assess the Effect of Single and Multiple Doses Org 50081 and a Single Dose of Zopiclone on Next-day Driving Ability and Psychomotor Performance in Healthy Volunteers. (P05794) (COMPLETED)

NCT ID: NCT00798395

Last Updated: 2015-10-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

32 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-10-31

Study Completion Date

2008-09-30

Brief Summary

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This trial is to investigate the effect on next-day driving performance and psychomotor performance in healthy volunteers.

Detailed Description

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Conditions

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Sleep Initiation and Maintenance Disorders Mental Disorders

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Treatment 1

Group Type EXPERIMENTAL

Org 50081

Intervention Type DRUG

1.5 mg on day 1-7

Treatment 2

Group Type EXPERIMENTAL

Org 50081

Intervention Type DRUG

4.5 mg on Day 1-7

Treatment 3

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Once daily on Day 1-7

Treatment 4

Group Type ACTIVE_COMPARATOR

zopiclone

Intervention Type DRUG

Single dose of 7.5 mg

Interventions

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Org 50081

1.5 mg on day 1-7

Intervention Type DRUG

Org 50081

4.5 mg on Day 1-7

Intervention Type DRUG

Placebo

Once daily on Day 1-7

Intervention Type DRUG

zopiclone

Single dose of 7.5 mg

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Subject has at least 3 years of car driving experience
* Subject signs the trial Informed Consent Form
* Subject is in a healthy condition as judged by the investigator
* Subject has a regular sleep pattern

Exclusion Criteria

* Subject has insomnia or any other sleep disorder
* Medication or drug use of any kind prior to the study
* Relevant history or presence of a significant medical illness
Minimum Eligible Age

21 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Merck Sharp & Dohme LLC

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Other Identifiers

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21105

Identifier Type: -

Identifier Source: secondary_id

P05794

Identifier Type: -

Identifier Source: org_study_id

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