A Study of Zolpidem Tartrate Sublingual Tablet in Adult Patients With Insomnia

NCT ID: NCT00466193

Last Updated: 2012-02-14

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

295 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-05-31

Study Completion Date

2007-11-30

Brief Summary

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The purpose of the study is to evaluate sleep onset following administration of zolpidem tartrate sublingual tablet (Intermezzo) versus placebo in adult insomnia patients.

Detailed Description

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Conditions

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Insomnia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Zolpidem 3.5mg

Group Type EXPERIMENTAL

zolpidem tartrate sublingual tablet

Intervention Type DRUG

3.5 milligram zolpidem tartrate sublingual tablet taken as needed following a middle-of-the-night awakening over the 28-night study period. Participants placed the study drug under the tongue and allowed it to dissolve there for about 2 minutes, then swallowed after dissolved.

Placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Placebo sublingual tablet taken as needed following a middle-of-the-night awakening over the 28-night study period. Participants placed the study drug under the tongue and allowed it to dissolve there for about 2 minutes, then swallowed after dissolved.

Interventions

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zolpidem tartrate sublingual tablet

3.5 milligram zolpidem tartrate sublingual tablet taken as needed following a middle-of-the-night awakening over the 28-night study period. Participants placed the study drug under the tongue and allowed it to dissolve there for about 2 minutes, then swallowed after dissolved.

Intervention Type DRUG

Placebo

Placebo sublingual tablet taken as needed following a middle-of-the-night awakening over the 28-night study period. Participants placed the study drug under the tongue and allowed it to dissolve there for about 2 minutes, then swallowed after dissolved.

Intervention Type DRUG

Other Intervention Names

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Intermezzo®

Eligibility Criteria

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Inclusion Criteria

* Adults with history of sleeplessness

Exclusion Criteria

* Allergic to investigational drug
* Any conditions and medications that may interfere with study drug evaluation
Minimum Eligible Age

18 Years

Maximum Eligible Age

64 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Transcept Pharmaceuticals

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Andrew Krystal, MD

Role: PRINCIPAL_INVESTIGATOR

Clinical Neurophysiology Training Program, Duke University

Thomas Roth, PhD

Role: PRINCIPAL_INVESTIGATOR

Sleep Disorders and Research Center, Henry Ford Hospital

Locations

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Transcept Investigational Site

Durham, North Carolina, United States

Site Status

Countries

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United States

Other Identifiers

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ZI-12

Identifier Type: -

Identifier Source: org_study_id

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