Relation of Circulating Endothelium-derived Microparticle to Carotid Atherosclerosis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

154 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-11-30

Study Completion Date

2013-11-30

Brief Summary

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The investigators hypothesized that circulating endothelium-derived microparticle (EMP) may be a useful surrogate marker of atherosclerosis and future episode of cerebrovascular events. Peripheral blood is drawn at the time of carotid ultrasound examination. Circulating EMPs are counted using flow-cytometry. The correlation among circulating EMP, ultrasound findings, and atherosclerotic risk factors are determined by multiple stepwise regression analysis. The prevalence of cerebrovascular events is also determined during 3-year follow-up period.

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Detailed Description

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Conditions

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Atherosclerosis

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Carotid atherosclerosis group

Patients who undergo carotid ultrasound examination for carotid atherosclerosis screening

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Patients who undergo carotid ultrasound examination for screening of atherosclerosis

Exclusion Criteria

* Cerebrovascular events within the last 12 months
* Acute coronary syndrome, coronary and peripheral intervention within the last 6 months
* Uncontrolled heart failure
* Other severe systemic diseases

Minimum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No