A Dose-Ranging Study Evaluating the Safety and Efficacy of IDP-108 in Patients With Onychomycosis

NCT ID: NCT00777868

Last Updated: 2012-06-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

135 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-10-31

Study Completion Date

2009-04-30

Brief Summary

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The purpose of this study is to assess the safety and effectiveness of two concentrations of IDP-108 in treating patients with onychomycosis

Detailed Description

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Conditions

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Onychomycosis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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1

Group Type EXPERIMENTAL

Low Strength IDP-108

Intervention Type DRUG

Topical application once a day for 9 months

2

Group Type EXPERIMENTAL

High Strength IDP-108

Intervention Type DRUG

Topical application once a day for 9 months

3

Group Type EXPERIMENTAL

High Strength IDP-108 under occlusion

Intervention Type DRUG

Topical application once a day for 9 months

4

Group Type PLACEBO_COMPARATOR

Vehicle

Intervention Type DRUG

Topical application once a day for 9 months

Interventions

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Low Strength IDP-108

Topical application once a day for 9 months

Intervention Type DRUG

High Strength IDP-108

Topical application once a day for 9 months

Intervention Type DRUG

High Strength IDP-108 under occlusion

Topical application once a day for 9 months

Intervention Type DRUG

Vehicle

Topical application once a day for 9 months

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Presence of onychomycosis of the target toenail
* A positive fungal culture from the target toenail

Exclusion Criteria

* Any disease or condition that might cause nail abnormalities or may interfere with clinical evaluations
* Presence of tinea pedis (athletes foot)
* Female subjects who are pregnant, nursing, planning a pregnancy, or become pregnant during the study
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Dow Pharmaceutical Sciences

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Unidad de Investigación en Salud

Chihuahua City, Chihuahua, Mexico

Site Status

Clinical Research Institute

Mexico City, Federal District, Mexico

Site Status

Hospital Central Militar

Mexico City, Federal District, Mexico

Site Status

Hospital General de México

México, Federal District, Mexico

Site Status

Instituto Dermatólogico de Jalisco "Dr. Jose Barba Rubio"

Guadalajara, Jalisco, Mexico

Site Status

Hospital Dr. Ángel Leaño

Zapopan, Jalisco, Mexico

Site Status

MIRC/OCA Hospital

Monterrey, Nuevo León, Mexico

Site Status

Centro de Dermatología de Monterrey

Monterrey, Nuevo León, Mexico

Site Status

Hospital Universitario "José E. González"

Monterrey, Nuevo León, Mexico

Site Status

Hospital Ignacio Morones Prieto SLP

San Luis Potosí City, San Luis Potosí, Mexico

Site Status

Countries

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Mexico

References

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Tschen EH, Bucko AD, Oizumi N, Kawabata H, Olin JT, Pillai R. Efinaconazole solution in the treatment of toenail onychomycosis: a phase 2, multicenter, randomized, double-blind study. J Drugs Dermatol. 2013 Feb;12(2):186-92.

Reference Type DERIVED
PMID: 23377392 (View on PubMed)

Other Identifiers

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DPSI-IDP-108-P2-01

Identifier Type: -

Identifier Source: org_study_id

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