Safety & Efficacy of NAB001 in the Treatment of Mild to Moderate Onychomycosis of the Toenails

NCT ID: NCT01208168

Last Updated: 2013-07-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

TERMINATED

Clinical Phase

PHASE3

Total Enrollment

468 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-09-30

Study Completion Date

2012-07-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The objectives of this study are to assess the safety of NAB001 for topical treatment of mild to moderate distal onychomycosis of the toenails over 52 weeks and to compare the efficacy of NAB001 to vehicle alone at the end of the study (Week 56) after treating for 52 weeks.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Onychomycosis

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Active drug

Group Type EXPERIMENTAL

NAB001

Intervention Type DRUG

nail lacquer, once daily, 52 weeks

Vehicle alone

Group Type PLACEBO_COMPARATOR

Vehicle alone

Intervention Type DRUG

nail lacquer, once daily, 52 weeks

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

NAB001

nail lacquer, once daily, 52 weeks

Intervention Type DRUG

Vehicle alone

nail lacquer, once daily, 52 weeks

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* mild to moderate fungal infection of the toenail as assessed by study doctor
* koh positive \& dermatophyte culture positive at Visit 1
* good general health as assessed by the study doctor

Exclusion Criteria

* severe fungal toenail infection
* prior use of antifungal drugs (wash-out allowed, duration varies on class)
* significant confounding conditions as assessed by study doctor
* pregnancy/lactation
* must forego nail salon procedures during study for at least \~60 weeks
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Promius Pharma, LLC

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Kent Allenby, MD

Role: STUDY_DIRECTOR

Promius Pharma

Joanne Fraser, PhD

Role: STUDY_DIRECTOR

Promius Pharma

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Phoenix, Arkansas, United States

Site Status

T. Joseph Raoof, MD, Inc.

Encino, California, United States

Site Status

Skin Surgery Medical Group, Inc.

San Diego, California, United States

Site Status

Longmont Medical Research Network

Longmont, Colorado, United States

Site Status

Jacksonville Center for Clinical Research

Jacksonville, Florida, United States

Site Status

Internaional Dermatology Research, Inc.

Miami, Florida, United States

Site Status

MedaPhase, Inc.

Newnan, Georgia, United States

Site Status

Clinical Research Atlanta

Stockbridge, Georgia, United States

Site Status

Northwest Clinical Trials

Boise, Idaho, United States

Site Status

Minnesota Clinical Study Center

Fridley, Minnesota, United States

Site Status

Gerard Furst, DPM, PLLC

East Setauket, New York, United States

Site Status

Dermatology Consulting Services

High Point, North Carolina, United States

Site Status

Wake Research Associates

Raleigh, North Carolina, United States

Site Status

Mazur Foot and Ankle

Salisbury, North Carolina, United States

Site Status

Radiant Research

Cincinnati, Ohio, United States

Site Status

Oregon Dermatology & Research Network

Portland, Oregon, United States

Site Status

Temple University - School of Podiatric Medicine

Philadelphia, Pennsylvania, United States

Site Status

Carolina Dermatology of Greenville, PA

Greenville, South Carolina, United States

Site Status

Coastal Carolina Research Center

Mt. Pleasant, South Carolina, United States

Site Status

Tennessee Clinical Research Center

Nashville, Tennessee, United States

Site Status

Ashton Podiatry Associates, PA

Dallas, Texas, United States

Site Status

Progressive Clinical Research

San Antonio, Texas, United States

Site Status

Instituto Dermatologica

Santo Domingo, , Dominican Republic

Site Status

Instituto Dermatologico

Santo Domingo, , Dominican Republic

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States Dominican Republic

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

0904

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

TDT 067 Onychomycosis Study
NCT01145807 UNKNOWN PHASE3