Dilapan Versus Laminaria

NCT ID: NCT00775983

Last Updated: 2013-11-14

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

72 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-10-31

Study Completion Date

2009-12-31

Brief Summary

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This is a randomized, blinded clinical trial comparing overnight laminaria versus same-day Dilapan for cervical preparation for surgical abortions occurring between fourteen and eighteen weeks gestation. Comparisons will be made between procedure time, need for additional dilation, occurrence of complications, and patient and provider satisfaction.

Hypothesis:

Cervical preparation for surgical abortion, between fourteen and eighteen weeks gestation, with same-day Dilapan is non-inferior to cervical preparation with overnight laminaria within a five-minute difference.

Primary objective:

Determine differences in procedure times

Secondary objectives:

Examine complications, and need for additional dilation between early second-trimester surgical abortions performed after cervical preparation with same-day Dilapan versus those performed after cervical preparation with overnight laminaria

Detailed Description

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Conditions

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Cervical Preparation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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laminaria

laminaria placed for cervical dilation; usual standard of care in study clinic

Group Type ACTIVE_COMPARATOR

laminaria

Intervention Type DEVICE

place device in cervix for dilation

Dilapan-S

experimental treatment

Group Type EXPERIMENTAL

Dilapan-S

Intervention Type DEVICE

Place in cervix for dilation.

Interventions

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laminaria

place device in cervix for dilation

Intervention Type DEVICE

Dilapan-S

Place in cervix for dilation.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Pregnancy between fourteen and eighteen weeks gestation
* Request for elective abortion and certainty of decision to proceed

Exclusion Criteria

* Incarceration
* Minor status (women younger than eighteen years)
* Allergy to Dilapan or laminaria
* Inability to speak and understand Spanish or English
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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University of California, San Francisco

OTHER

Sponsor Role lead

Responsible Party

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Eleanor Drey, MD

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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San Francisco General Hospital

San Francisco, California, United States

Site Status

Countries

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United States

References

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Newmann SJ, Sokoloff A, Tharyil M, Illangasekare T, Steinauer JE, Drey EA. Same-day synthetic osmotic dilators compared with overnight laminaria before abortion at 14-18 weeks of gestation: a randomized controlled trial. Obstet Gynecol. 2014 Feb;123(2 Pt 1):271-278. doi: 10.1097/AOG.0000000000000080.

Reference Type DERIVED
PMID: 24402587 (View on PubMed)

Other Identifiers

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1176030877

Identifier Type: -

Identifier Source: org_study_id