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Identification of Novel Targets for Regulation of Adipose Tissue Mass

NCT ID: NCT00773565

Last Updated: 2012-08-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

62 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-10-31

Study Completion Date

2011-08-31

Brief Summary

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The aim of this study is to understand the metabolic changes occurring in fat tissue both during controlled weight loss that lead to the improvement of type 2 diabetes and other obesity associated metabolic disorders. The novelty of the study is the analysis of preadipocytes, a poorly characterized subfraction of the adipose tissue, which provides adipocyte precursors and thereby strongly influences adipose tissue mass changes. Knowledge of pathways involved in controlling adipose tissue composition will help to design novel intervention strategies for the treatment of obesity associated metabolic disorders such as type 2 diabetes.

Detailed Description

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Conditions

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Obesity

Keywords

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patients with obesity (BMI > 30 kg/m2)

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Optifast

Patients included take part at a weight reduction program over one year.

Group Type OTHER

Optifast

Intervention Type DIETARY_SUPPLEMENT

Formula diet for twelve weeks combined with physical activity and behavioral therapy

Interventions

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Optifast

Formula diet for twelve weeks combined with physical activity and behavioral therapy

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Participants of the OPTIFAST52 program
* BMI \> 30 kg/m2

Exclusion Criteria

* Rejection of informed consent by the participant
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Swiss Federal Institute of Technology

OTHER

Sponsor Role collaborator

Gottfried Rudofsky

OTHER

Sponsor Role lead

Responsible Party

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Gottfried Rudofsky

Oberarzt

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Christian Wolfrum, PhD

Role: STUDY_CHAIR

ETH Zürich

Locations

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University Hospital Heidelberg

Heidelberg, , Germany

Site Status

Countries

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Germany

Other Identifiers

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EFSD-CRP-2008

Identifier Type: -

Identifier Source: org_study_id