A Study on the Efficacy and Safety of Nebivolol Monotherapy in Hispanic Hypertensive Patients

NCT ID: NCT00770861

Last Updated: 2011-01-26

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

277 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-09-30

Brief Summary

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This study will evaluate the efficacy and safety of nebivolol monotherapy in Hispanic patients with stage 1 or stage 2 hypertension

Detailed Description

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Conditions

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Hypertension

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Nebivolol

Nebivolol 5 mg, 5-mg Nebivolol nontrade tablets, oral administration ; Nebivolol 10 mg, 10-mg Nebivolol nontrade tablets, oral administration ; Nebivolol 20 mg, 20-mg Nebivolol nontrade tablets, oral administration ; Nebivolol 40 mg, two 20-mg Nebivolol nontrade tablets, oral administration

Group Type ACTIVE_COMPARATOR

Nebivolol

Intervention Type DRUG

Nebivolol 5 mg, 5-mg Nebivolol nontrade tablets , oral administration Nebivolol 10 mg, 10-mg Nebivolol nontrade tablets , oral administration Nebivolol 20 mg, 20-mg Nebivolol nontrade tablets , oral administration Nebivolol 40 mg, two 20-mg Nebivolol nontrade tablets , oral administration

Placebo

Matching placebo tablets, oral administration

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Matching placebo tablets, oral administration

Interventions

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Nebivolol

Nebivolol 5 mg, 5-mg Nebivolol nontrade tablets , oral administration Nebivolol 10 mg, 10-mg Nebivolol nontrade tablets , oral administration Nebivolol 20 mg, 20-mg Nebivolol nontrade tablets , oral administration Nebivolol 40 mg, two 20-mg Nebivolol nontrade tablets , oral administration

Intervention Type DRUG

Placebo

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Intervention Type DRUG

Other Intervention Names

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Bystolic (TM)

Eligibility Criteria

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Inclusion Criteria

* Male and female outpatients 18 to 80 years of age, self-identified as Hispanic or Latino ethnicity
* Females must be post-menopausal, or not pregnant and using an approved contraceptive regimen
* Meet criteria for stage I or II hypertension
* Currently not treated, or being treated with no more than two anti-hypertensive medications

Exclusion Criteria

* Secondary hypertension
* Are taking three or more antihypertensive agents
* Have uncontrolled or poorly controlled diabetes mellitus type I or type II
* Evidence of other concurrent disease or conditions that might interfere with the conduct of the study
* Participation in any investigational study within 30 days of Screening (Visit 1).
* Have a history of hypersensitivity to nebivolol or other β-blockers, or any contraindication to β-blocker use
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Forest Laboratories

INDUSTRY

Sponsor Role lead

Responsible Party

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Forest Research Institute, a Subsidiary of Forest Laboratories Inc.

Principal Investigators

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Tatjana Lukic, MD., M.Sc.

Role: STUDY_DIRECTOR

Forest Research Institute, a subsidiary of Forest Laboratories Inc.

Locations

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Forest Investigative Site

Buena Park, California, United States

Site Status

Forest Investigative Site

Chino, California, United States

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Forest Investigative Site

Long Beach, California, United States

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Forest Investigative Site

Los Angeles, California, United States

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Forest Investigative Site

National City, California, United States

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Forest Investigative Site

San Bernardino, California, United States

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Forest Investigative Site

Temecula, California, United States

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Forest Investigative Site

Tustin, California, United States

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Forest Investigative Site

Coral Gables, Florida, United States

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Forest Investigative Site FL2

Hialeah, Florida, United States

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Forest Investigative Site

Hialeah, Florida, United States

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Forest Investigative Site

Hialeah, Florida, United States

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Forest Investigative Site

Kissimmee, Florida, United States

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Forest Investigative Site

Miami, Florida, United States

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Forest Investigative Site

Miami, Florida, United States

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Forest Investigative Site

Miami, Florida, United States

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Forest Investigative Site

Pembroke Pines, Florida, United States

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Forest Investigative Site

Pembroke Pines, Florida, United States

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Forest Investigative Site

West Palm Beach, Florida, United States

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Forest Investigative Site

Atlanta, Georgia, United States

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Forest Investigative Site

Atlanta, Georgia, United States

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Forest Investigative Site

New Windsor, New York, United States

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Forest Investigative Site

The Bronx, New York, United States

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Forest Investigative Site

Carrollton, Texas, United States

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Forest Investigative Site

Corpus Christi, Texas, United States

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Forest Investigative Site

Dallas, Texas, United States

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Forest Investigative Site

El Paso, Texas, United States

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Forest Investigative Site

San Antonio, Texas, United States

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Forest Investigative Site

San Antonio, Texas, United States

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Forest Investigative Site

Ponce, , Puerto Rico

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Forest Investigative Site

Salinas, , Puerto Rico

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Forest Investigative Site

Santurce, , Puerto Rico

Site Status

Countries

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United States Puerto Rico

Other Identifiers

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NEB-MD-16

Identifier Type: -

Identifier Source: org_study_id

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