Study Evaluating the Impact of the 13-valent Pneumococcal Conjugate Vaccine (13vPnC) in Alaskan Native Children.

NCT ID: NCT00743652

Last Updated: 2012-03-15

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

373 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-01-31

Study Completion Date

2010-09-30

Brief Summary

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This study is to evaluate the safety, immunogenicity and impact of 13-valent Pneumococcal conjugate vaccine in Alaskan Native Children.

Detailed Description

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Conditions

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Pneumococcal Disease 13-valent Pneumococcal Vaccine

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Group1

Subjects 6 weeks to \<10 months of age with 0 prior dose of Prevnar.

Group Type EXPERIMENTAL

13-valent Pneumococcal Conjugate Vaccine

Intervention Type BIOLOGICAL

4 doses of 13vPnC (0.5ml, IM) will be administered. (3 doses infant series, and 1 toddler dose)

Group 2

Subjects \<12 months of age with 1 prior dose of Prevnar.

Group Type EXPERIMENTAL

13-valent Pneumococcal Conjugate Vaccine

Intervention Type BIOLOGICAL

3 doses of 13vPnC (0.5ml, IM) will be administered. (2 doses for infant series catch-up, and 1 toddler dose)

Group 3

Subjects \<12 months of age with 2 prior doses of Prevnar.

Group Type EXPERIMENTAL

13-valent Pneumococcal Conjugate Vaccine

Intervention Type BIOLOGICAL

2 doses of 13vPnC (0.5ml, IM) will be administered. (1 dose infant series catch-up, and 1 toddler dose)

Group 4

Subjects ≥12 months to \<2 years of age.

Group Type EXPERIMENTAL

13-valent Pneumococcal Conjugate Vaccine

Intervention Type BIOLOGICAL

2 doses of 13vPnC (0.5ml, IM) will be administered. (2 catch-up dose(s) greater than 60 days apart )

Group 5

Subjects ≥2 years to \<5 years of age

Group Type EXPERIMENTAL

13-valent Pneumococcal Conjugate Vaccine

Intervention Type BIOLOGICAL

1 dose of 13vPnC (0.5ml, IM) will be administered. (1 catch-up dose)

Interventions

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13-valent Pneumococcal Conjugate Vaccine

4 doses of 13vPnC (0.5ml, IM) will be administered. (3 doses infant series, and 1 toddler dose)

Intervention Type BIOLOGICAL

13-valent Pneumococcal Conjugate Vaccine

3 doses of 13vPnC (0.5ml, IM) will be administered. (2 doses for infant series catch-up, and 1 toddler dose)

Intervention Type BIOLOGICAL

13-valent Pneumococcal Conjugate Vaccine

2 doses of 13vPnC (0.5ml, IM) will be administered. (1 dose infant series catch-up, and 1 toddler dose)

Intervention Type BIOLOGICAL

13-valent Pneumococcal Conjugate Vaccine

2 doses of 13vPnC (0.5ml, IM) will be administered. (2 catch-up dose(s) greater than 60 days apart )

Intervention Type BIOLOGICAL

13-valent Pneumococcal Conjugate Vaccine

1 dose of 13vPnC (0.5ml, IM) will be administered. (1 catch-up dose)

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Male or female infants 6 weeks to \< 5years of age in good health, available for the entire study period and reachable by phone, parents able to complete all relevant study procedures.
* Infants who have received Prevnar are eligible to participate, but this is not required.
* Infants participating in the blood draws must live in a specific identified area (Yukon Kuskokwim Delta region)

Exclusion Criteria

* Contraindication to vaccination with pneumococcal vaccine or allergic reaction to any vaccines or vaccine related components, immune deficiency, bleeding disorder or major known congenital malformation.
Minimum Eligible Age

42 Days

Maximum Eligible Age

5 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Pfizer

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pfizer CT.gov Call Center

Role: STUDY_DIRECTOR

Pfizer

Locations

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Pfizer Investigational Site

Akiak, Alaska, United States

Site Status

Pfizer Investigational Site

Bethel, Alaska, United States

Site Status

Pfizer Investigational Site

Chefornak, Alaska, United States

Site Status

Pfizer Investigational Site

Chevak, Alaska, United States

Site Status

Pfizer Investigational Site

Eek, Alaska, United States

Site Status

Pfizer Investigational Site

Emmonak, Alaska, United States

Site Status

Pfizer Investigational Site

Hooper Bay, Alaska, United States

Site Status

Pfizer Investigational Site

Kalskag, Alaska, United States

Site Status

Pfizer Investigational Site

Kasigluk, Alaska, United States

Site Status

Pfizer Investigational Site

Kongiganak, Alaska, United States

Site Status

Pfizer Investigational Site

Kotlik, Alaska, United States

Site Status

Pfizer Investigational Site

Kwethluk, Alaska, United States

Site Status

Pfizer Investigational Site

Kwigillingok, Alaska, United States

Site Status

Pfizer Investigational Site

Mountain Village, Alaska, United States

Site Status

Pfizer Investigational Site

Napaskiak, Alaska, United States

Site Status

Pfizer Investigational Site

Newtok, Alaska, United States

Site Status

Pfizer Investigational Site

Nunapitchuk, Alaska, United States

Site Status

Pfizer Investigational Site

Russian Mission, Alaska, United States

Site Status

Pfizer Investigational Site

Scammon Bay, Alaska, United States

Site Status

Pfizer Investigational Site

Toksook Bay, Alaska, United States

Site Status

Pfizer Investigational Site

Tuluksak, Alaska, United States

Site Status

Countries

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United States

Related Links

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Other Identifiers

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B1851009

Identifier Type: -

Identifier Source: secondary_id

6096A1-3010

Identifier Type: -

Identifier Source: org_study_id

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