The Therapeutic Efficacy of Neurofeedback in Depression

NCT ID: NCT00729547

Last Updated: 2008-08-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-09-30

Study Completion Date

2007-01-31

Brief Summary

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The investigators examined the therapeutic efficacy of neurofeedback in depression subjects. The investigators hypothesize that 5 weeks neurofeedback training will be able to alleviate depressive symptoms.

Detailed Description

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Subject

* Fulfilled DSM-IV criteria for depressive disorders.
* Persons who had organic disorders were excluded.
* Who had been treated by psychoactive drugs for at least 2 months prior to the study were excluded.

Design

* Subjects were randomly assigned to two groups (EEG biofeedback /psychotherapy placebo) by block randomization.
* EEG biofeedback training was provided for 5 weeks(10 sessions, twice per week). Each training session was composed of 6 four minute trials followed by 5 thirty second rest periods
* Psychotherapy placebo session was provided for 5 weeks. These sessions consisted of additional assessment, interpretation of the test results and providing information on course and treatment of mood disorder.
* After subjects completed the training, they participated in a month-long (twice per week) self-training session to maintain a similar mental state during neurofeedback training sessions without feedback system's assistance.
* Subjects who had finished the psychotherapy placebo were referred to other therapists as necessary.

Conditions

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Depression

Keywords

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Depression Biofeedback Psychophysiology

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

FACTORIAL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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2

Psychotherapy placebo session

Group Type PLACEBO_COMPARATOR

Psychotherapy placebo

Intervention Type BEHAVIORAL

These sessions consisted of additional assessment, interpretation of the test results and providing information on course and treatment of mood disorder.

1

Neurofeedback training which enhance left frontal alpha wave.

Group Type EXPERIMENTAL

Neurofeedback

Intervention Type BEHAVIORAL

enhance relative activity level of left frontal activity

Interventions

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Neurofeedback

enhance relative activity level of left frontal activity

Intervention Type BEHAVIORAL

Psychotherapy placebo

These sessions consisted of additional assessment, interpretation of the test results and providing information on course and treatment of mood disorder.

Intervention Type BEHAVIORAL

Other Intervention Names

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Asymmetry training

Eligibility Criteria

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Inclusion Criteria

* clinical diagnosis of mood disorder
* right handed
* current BDI-2 score exceed 10

Exclusion Criteria

* with psychotic symptom
* with organic disorders
* treated by psychoactive drugs for at least 2 months prior to the study
* history of pathologic alcohol use
Minimum Eligible Age

20 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Korea Research Foundation

OTHER

Sponsor Role collaborator

Kyunghee University

OTHER

Sponsor Role collaborator

Korea University

OTHER

Sponsor Role lead

Responsible Party

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Department of Psychology, Korea University

Principal Investigators

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Hyuntaek Kim, PHD

Role: PRINCIPAL_INVESTIGATOR

Department of Psychology, Korea university

Locations

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Department of Oriental Neuropsychiatry, Kyunghee Medical Center

Seoul, Seoul, South Korea

Site Status

Countries

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South Korea

References

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Hammond DC. Neurofeedback with anxiety and affective disorders. Child Adolesc Psychiatr Clin N Am. 2005 Jan;14(1):105-23, vii. doi: 10.1016/j.chc.2004.07.008.

Reference Type BACKGROUND
PMID: 15564054 (View on PubMed)

Rosenfeld JP. An EEG biofeedback protocol for affective disorders. Clin Electroencephalogr. 2000 Jan;31(1):7-12. doi: 10.1177/155005940003100106. No abstract available.

Reference Type BACKGROUND
PMID: 10638347 (View on PubMed)

Kumano H, Horie H, Shidara T, Kuboki T, Suematsu H, Yasushi M. Treatment of a depressive disorder patient with EEG-driven photic stimulation. Biofeedback Self Regul. 1996 Dec;21(4):323-34. doi: 10.1007/BF02214432.

Reference Type RESULT
PMID: 9031711 (View on PubMed)

Rosenfeld JP, Cha G, Blair T, Gotlib IH. Operant (biofeedback) control of left-right frontal alpha power differences: potential neurotherapy for affective disorders. Biofeedback Self Regul. 1995 Sep;20(3):241-58. doi: 10.1007/BF01474516.

Reference Type RESULT
PMID: 7495918 (View on PubMed)

Saxby E, Peniston EG. Alpha-theta brainwave neurofeedback training: an effective treatment for male and female alcoholics with depressive symptoms. J Clin Psychol. 1995 Sep;51(5):685-93. doi: 10.1002/1097-4679(199509)51:53.0.co;2-k.

Reference Type RESULT
PMID: 8801245 (View on PubMed)

Related Links

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http://www.psychonews.co.kr

click here to review subject recruiting and information on this study

http://psy.korea.ac.kr

click here to see brief description of the department of psychology at Korea university

http://www.khmc.or.kr

click here to review the location of this study and the policy of IRB

Other Identifiers

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KRF-2005-079-HS0012

Identifier Type: -

Identifier Source: org_study_id