Study to Assess Safety and Efficacy of DF01 in Reducing Prolonged Labor

NCT ID: NCT00710242

Last Updated: 2009-05-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

263 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-04-30

Study Completion Date

2009-05-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The study is a Proof-of-concept study to evaluate if DF01 can prevent protracted labor. Time to delivery will be measured from the time of at least 3 cm cervix dilatation and 3 contractions of minimum one minute's duration/10 minutes.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Pregnancy Labor

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

1

DF01

Group Type EXPERIMENTAL

DF01

Intervention Type DRUG

Once daily s.c. injections from approximately 3-7 days before expected delivery (maximum 2 weeks before) until delivery (maximum 2 weeks after expected delivery)

2

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Once daily s.c. injections from approximately 3-7 days before expected delivery (maximum 2 weeks before) until delivery (maximum 2 weeks after expected delivery)

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

DF01

Once daily s.c. injections from approximately 3-7 days before expected delivery (maximum 2 weeks before) until delivery (maximum 2 weeks after expected delivery)

Intervention Type DRUG

Placebo

Once daily s.c. injections from approximately 3-7 days before expected delivery (maximum 2 weeks before) until delivery (maximum 2 weeks after expected delivery)

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* healthy nulliparous females
* normal singleton pregnancy
* intact membranes

Exclusion Criteria

* breech or other abnormal presentation
* intercurrent illness
* pregnancy complications
* vaginal bleeding in third trimester
* etc
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Dilafor AB

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Dilafor AB

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Lena Granstrom, MD

Role: PRINCIPAL_INVESTIGATOR

Kvinnokliniken Sodra Alvsborgs sjukhus Boras

Gunvor Ekman-Ordeberg, MD, PhD

Role: STUDY_CHAIR

Dilafor AB

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Kvinnokliniken Alvsborgs sjukhus Boras

Borås, , Sweden

Site Status

Gavle sjukhus

Gävle, , Sweden

Site Status

Sahlgrenska/Ostra sjukhuset

Gothenburg, , Sweden

Site Status

Karolinska Universistetssjuhuset

Huddinge, , Sweden

Site Status

Lanssjukhuset Ryhov

Jönköping, , Sweden

Site Status

Lanssjukhuset

Kalmar, , Sweden

Site Status

Universitetssjukhuset

Linköping, , Sweden

Site Status

Universitetssjukhuset

Lund, , Sweden

Site Status

Vrinnevisjukhuset

Norrköping, , Sweden

Site Status

Nyköpings lasarett

Nyköping, , Sweden

Site Status

Universitetssjukhuset

Örebro, , Sweden

Site Status

Kärnsjukhuset

Skövde, , Sweden

Site Status

Danderyds sjukhus

Stockholm, , Sweden

Site Status

Sodersjukhuset

Stockholm, , Sweden

Site Status

Norra Älvsborgs länssjukhus

Trollhättan, , Sweden

Site Status

Akademiska sjukhuset

Uppsala, , Sweden

Site Status

Centrallasarettet

Vaxjo, , Sweden

Site Status

Centrallasarettet

Västerås, , Sweden

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Sweden

References

Explore related publications, articles, or registry entries linked to this study.

Ekman-Ordeberg G, Hellgren-Wangdahl M, Jeppson A, Rahkonen L, Blomberg M, Pettersson K, Bejlum C, Engberg M, Ludvigsen M, Uotila J, Tihtonen K, Hallberg G, Jonsson M. Tafoxiparin, a novel drug candidate for cervical ripening and labor augmentation: results from 2 randomized, placebo-controlled studies. Am J Obstet Gynecol. 2024 Mar;230(3S):S759-S768. doi: 10.1016/j.ajog.2022.10.013. Epub 2023 May 17.

Reference Type DERIVED
PMID: 38462256 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

PPL02

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Drotaverine to Shorten the Length of Labor
NCT01639027 COMPLETED PHASE2/PHASE3
Anticholinergics for Cervical Edema in Labor
NCT06702670 NOT_YET_RECRUITING PHASE2/PHASE3