Assessment of Circulating Copeptin Levels in Healthy Subjects and Patients With Renal Insufficiency After Oral Water Load and Hypertonic Saline Infusion

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-07-31

Study Completion Date

2009-10-31

Brief Summary

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The are 2 principal goals in this study:

1. To measure plasma copeptin levels in healthy subjects and to correlate them with plasma AVP concentrations and urine osmolalities in iso-, hypo-, and hyperosmolar states.
2. To measure plasma copeptin concentrations in patients with chronic renal failure under the same conditions described above, in order to characterize the impact of renal function on circulating copeptin levels in correlation to plasma AVP and urine osmolality.

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Detailed Description

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Conditions

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Hypoosmolality Hyperosmolality Renal Failure

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* chronic renal failure grade I through IV
* healthy age-matched controls

Exclusion Criteria

* chronic renal failure grade V
* heart failure
* liver disease
* nephrotic syndrome
* anemia (hemoglobin level \< 100 g/L)
* uncontrolled hypertension (systolic BP \> 160 mmHg; diastolic BP \> 95 mm Hg)
* coexisting severe disease
* known thyroid disease
* known hypocortisolism
* known hypercortisolism
* known diabetes insipidus
* pregnancy
* lactation

Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes