Clinical Evaluation of the Effect of Duodenal-Jejunal Bypass on Type 2 Diabetes

NCT ID: NCT00694278

Last Updated: 2008-06-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

15 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-06-30

Brief Summary

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The aim of this study and the primary outcome is to clinically evaluate effect of laparoscopic duodenal-jejunal bypass on non-obese type 2 diabetes. Secondary outcomes will evaluate CCK, FFA, Cholesterol Ghrelin, C-peptide, and HbA1c levels. Patients will be followed closely to ensure the desired results are sustained in long term

Detailed Description

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Conditions

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Type II Diabetes

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

CROSS_SECTIONAL

Eligibility Criteria

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Inclusion Criteria

* Adults age 20-65 years
* Clinical diagnosis of type II diabetes buy on of the following three criteria (American Diabetes Association)

1. A normal or high C-peptide level (to exclude type 1 diabetes) (\>.9ng/ml)
2. A random plasma glucose of 200mg/dl or more with typical symptom of diabetes
3. A fasting plasma glucose of 126mg/dl or more on more than one occasion
* BMI 22-34 KG/m2
* Patients on oral hypoglycemic medications or insulin to control T2DM
* Inadequate control of diabetes as defined as HbA1c\>7.5
* No contraindication for surgery or General Anesthesia as determined by multidisciplinary surgical team
* Ability to understand and describe the mechanism of action of ricks and benefits of the operation

Exclusion Criteria

* Enrolled in another clinical study which involves and investigational drug
* Diagnosis type 1 diabetes
* Pregnancy (all female patients will have beta HCG) or planned pregnancy within 2 years of entry into the study or unwilling to use reliable contraceptive method
* Previous gastric or esophageal surgery
* Immunosuppressive drugs including corticosteroids
* Coagulopathy (INR\>1.5 or platelets\<50,000/ul)
* Anemia (Hgb\<10.0g/dl)
Minimum Eligible Age

20 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Ferzli, George S., M.D. F.A.C.S.

INDIV

Sponsor Role lead

Responsible Party

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Lutheran Medical Center

Principal Investigators

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George Ferzli, MD

Role: STUDY_CHAIR

Lutheran Medical Center

Locations

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Lutheran Medical Center

Brooklyn, New York, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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George Ferzli, MD

Role: CONTACT

Phone: 718-630-7351

Email: [email protected]

Facility Contacts

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George Ferzli, MD

Role: primary

Other Identifiers

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LMC95

Identifier Type: -

Identifier Source: org_study_id