A Study of Once-Monthly Subcutaneous Mircera for the Treatment of Chronic Renal Anemia in Pre-Dialysis Patients Not Currently Treated With ESA.

NCT ID: NCT00680563

Last Updated: 2013-11-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE3

Total Enrollment

4 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-04-30

Study Completion Date

2010-01-31

Brief Summary

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This single arm study will assess the efficacy and safety of subcutaneous Mircera for the correction and maintenance of hemoglobin levels in predialysis patients with renal anemia who are not currently treated with ESA. Eligible patients will receive monthly subcutaneous injections at an initial recommended dose of 1.2 micrograms/kg. The anticipated time on study treatment is 3-12 months, and the target sample size is 100-500 individuals.

Detailed Description

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Conditions

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Anemia

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1

Group Type EXPERIMENTAL

methoxy polyethylene glycol-epoetin beta [Mircera]

Intervention Type DRUG

sc every month (starting dose 1.2 micrograms/kg)

Interventions

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methoxy polyethylene glycol-epoetin beta [Mircera]

sc every month (starting dose 1.2 micrograms/kg)

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* adult patients, \>=18 years of age;
* chronic renal anemia;
* no ESA therapy during previous 3 months;
* adequate iron status;
* rapid chronic kidney disease progression.

Exclusion Criteria

* transfusion of red blood cells during previous 2 months;
* poorly controlled hypertension requiring hospitalization in previous 6 months;
* significant acute or chronic bleeding.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hoffmann-La Roche

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Clinical Trials

Role: STUDY_DIRECTOR

Hoffmann-La Roche

Locations

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Buenos Aires, , Argentina

Site Status

La Plata, , Argentina

Site Status

San Miguel de Tucumán, , Argentina

Site Status

Blumenau, , Brazil

Site Status

Botucatu, , Brazil

Site Status

Curitiba, , Brazil

Site Status

Rio de Janeiro, , Brazil

Site Status

São Paulo, , Brazil

Site Status

São Paulo, , Brazil

Site Status

Santiago, , Chile

Site Status

Santiago, , Chile

Site Status

Barranquilla, , Colombia

Site Status

Cali, , Colombia

Site Status

Envigado, , Colombia

Site Status

Medellín, , Colombia

Site Status

San José, , Costa Rica

Site Status

Quito, , Ecuador

Site Status

Guatemala City, , Guatemala

Site Status

Panama City, , Panama

Site Status

Lima, , Peru

Site Status

San Isidro, , Peru

Site Status

Caracas, , Venezuela

Site Status

Countries

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El Salvador Mexico Uruguay Argentina Brazil Chile Colombia Costa Rica Ecuador Guatemala Panama Peru Venezuela

Other Identifiers

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ML21467

Identifier Type: -

Identifier Source: org_study_id